ArticleNature communications2026
A quantitative approach for defining the degradability landscape of protein degraders.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Targeted protein degradation (TPD) is an emerging therapeutic modality, but how multiple factors jointly determine degradation efficacy remains poorly understood. Here we present a quantitative framework for modeling the cellular mechanism of action of TPD, allowing for prediction of cellular efficacy with practically obtainable parameters. Applying this model to published data on 41 targets reveals a common range of degradation rate between 0.1 and 10 min
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