Evidence map›Paper›PMID 42443174›Full record

ArticleNature communications2026

Transcriptomic analysis of tissue-resident memory T cells of the fallopian tube reveals a precursor immune surveillance network for ovarian cancer prevention.

Luyao Wang, Breeshey Roskams-Hieter, Nosheen Hussain, Joel Nulsen, Aneesh Aggarwal, May Sallam, Lili Wang, Lena Rai, Hui Shi, Amro Ahmed-Ebbiary and 8 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Luyao WangOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0008-0952-494X
Breeshey Roskams-HieterNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Nosheen HussainOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Joel NulsenSingula Bio, Oxford, UK.
Aneesh AggarwalOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
May SallamOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Lili WangSingula Bio, Oxford, UK.
Lena RaiOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9681-2190
Hui ShiOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Amro Ahmed-EbbiarySingula Bio, Oxford, UK.
Aws Al-DekaSingula Bio, Oxford, UK.ORCID http://orcid.org/0000-0002-8138-2981
Takashi TakedaOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Mara ArtibaniOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Hooman Soleymani MajdDepartment of Gynecological Oncology, Churchill Hospital, Oxford University Hospitals, Oxford, UK.ORCID http://orcid.org/0000-0003-3293-5321
Jason YapPan Birmingham Gynaecological Cancer Centre, Midland Metropolitan University Hospital, Smethwick, UK.
Christopher YauNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7615-8523
Nancy ZaarourOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. nancy.zaarour@lincoln.ox.ac.uk.ORCID http://orcid.org/0009-0002-9084-7178
Ahmed Ashour AhmedOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. ahmed.ahmed@wrh.ox.ac.uk.ORCID http://orcid.org/0000-0001-6509-2581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fallopian tube (FT) is increasingly recognized as the origin of high-grade serous ovarian cancer (HGSOC), yet its immune landscape remains poorly understood. Here, we employ single-cell RNA sequencing and paired T-cell receptor sequencing to profile tissue-resident memory-like T cells (TRML) from patient-derived matched non-cancerous FT, metastatic tumors, and peripheral blood. We identify substantial clonal and functional overlap (18.4%) between FT-derived and tumor-infiltrating TRMLs, exceeding that of circulating T cells. Shared clonotypes are preferentially enriched in exhausted CD8+ subsets, including a previously uncharacterized SIK3-high subset linked to epigenetic plasticity and metabolic adaptation. Functionally, FT-derived TRMLs recognize autologous tumor antigens, showing strong interferon-γ (IFN-γ) responses and CD137 upregulation in organoid coculture assays, supporting a role in early immune surveillance. Notably, FT TRMLs exhibit lower exhaustion than tumor counterparts, suggesting therapeutic potential. These findings reveal a precursor immune surveillance network in the FT and support leveraging FT-resident T cells for cancer immunotherapy and prevention.

Indexed as

Fallopian TubesImmunologic SurveillanceMemory T CellsOvarian NeoplasmsAntigens, NeoplasmCD8-Positive T-LymphocytesFemaleGene Expression ProfilingHumansImmunologic MemoryInterferon-gammaLymphocytes, Tumor-InfiltratingT-Cell ExhaustionTranscriptomeAntigens, NeoplasmInterferon-gamma

Identifiers

PMID42443174
PMCPMC13486501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.