Evidence map›Paper›PMID 42443153›Full record

ArticleCell death & disease2026

Restoring the CD226 in CD8

Liyi Zhang, Jiaoduan Li, Bingqiu Xiu, Chen Zheng, Qi Zhang, Huixin Lu, Zehao Wang, Zhibo Shao, Jingyan Xue, Yayun Chi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liyi Zhang *Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, PR China.ORCID http://orcid.org/0000-0002-9731-4385
Jiaoduan Li *Department of Dermatology, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, PR China.
Bingqiu Xiu *Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, PR China.ORCID http://orcid.org/0000-0002-0771-591X
Chen ZhengDepartment of Oncology, Fudan University Shanghai Medical College, Shanghai, PR China.
Qi ZhangDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, PR China.
Huixin LuDepartment of Breast Surgery, Fudan University Shanghai Cancer Center Xiamen Hospital, Xiamen, PR China.
Zehao WangDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, PR China.
Zhibo ShaoDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, PR China.
Jingyan XueDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, PR China.
Yayun ChiDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, PR China.
Dongxi XiangState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Department of Biliary-Pancreatic Surgery, Department of Gastrointestinal Surgery, Shanghai Key Laboratory of Cancer System Regulation and Clinical Translation, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. dxiang@shsmu.edu.cn.
Jiong WuDepartment of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, PR China. wujiong1122@vip.sina.com.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82002795National Natural Science Foundation of China (National Science Foundation of China) 82072919National Natural Science Foundation of China (National Science Foundation of China) 82173274National Natural Science Foundation of China (National Science Foundation of China) 82373357Natural Science Foundation of Fujian Province (Fujian Provincial Natural Science Foundation) 2024J08318Natural Science Foundation of Fujian Province (Fujian Provincial Natural Science Foundation) 2025J01320677Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 23141901000
6 · The paper itself

Abstract

Immune checkpoint blockade (ICB) has shown limited activity in HER2

Indexed as

Antigens, Differentiation, T-LymphocyteBreast NeoplasmsCD8-Positive T-LymphocytesErb-b2 Receptor Tyrosine KinasesReceptors, ImmunologicAnimalsFemaleHumansMiceT Lineage-Specific Activation Antigen 1Tumor MicroenvironmentAntigens, Differentiation, T-LymphocyteERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesReceptors, ImmunologicTIGIT protein, humanT Lineage-Specific Activation Antigen 1

Identifiers

PMID42443153
PMCPMC13642357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.