Evidence map›Paper›PMID 42443037›Full record

ArticleTrends in cancer2026

Neural checkpoint therapy in lung cancer.

Glori Das, Hong Zhao, Stephen T C Wong

Abstract read
In one paragraph

Article in Trends in cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Glori DasT. T. and W. F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist, Houston, TX 77030, USA; Texas A&M University College of Medicine, Bryan, TX 77807, USA.
Hong ZhaoT. T. and W. F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist, Houston, TX 77030, USA; Department of Medicine, Houston Methodist Hospital and Weill Cornell Medicine, New York, NY, USA. Electronic address: hzhao@houstonmethodist.org.
Stephen T C WongT. T. and W. F. Chao Center for BRAIN, Houston Methodist Neal Cancer Center, Houston Methodist, Houston, TX 77030, USA; Texas A&M University College of Medicine, Bryan, TX 77807, USA; Department of Medicine, Houston Methodist Hospital and Weill Cornell Medicine, New York, NY, USA.

Funding

Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumorsR01CA238727 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI WONG, STEPHEN TC, ZHAO, HONG · 2020 to 2024
$2.6M
NCI NIH HHS R01 CA238727
6 · The paper itself

Abstract

Sensory nerves are emerging as regulators of tumor immunity. A newly identified Nav1.8+ neuron-calcitonin gene-related peptide axis in lung adenocarcinoma links nociceptive signaling to impaired tertiary lymphoid structure formation and immune escape, suggesting that neural checkpoint blockade may help remodel immune-cold tumors and improve immunotherapy responses (Ho et al.).

Indexed as

Immune Checkpoint InhibitorsLung NeoplasmsAnimalsCalcitonin Gene-Related PeptideHumansImmunotherapySensory Receptor CellsSignal TransductionTumor EscapeCalcitonin Gene-Related PeptideImmune Checkpoint InhibitorsCGRPimmunotherapylung cancerneuroimmune signalingtertiary lymphoid structurestumor innervation

Identifiers

PMID42443037
PMCPMC13372209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.