Evidence map›Paper›PMID 42442716›Full record

ArticleRespirology (Carlton, Vic.)2026

Biomarkers of Pre-COPD Lung Function Trajectories in Middle Age: A Prospective Study From 1st to 6th Decade.

Dinh S Bui, Don Vicendese, Jonathan Pham, Nur Sabrina Idrose, Adrian Lowe, Caroline Lodge, Raisa Cassim, Chamara Senaratna, Gayan Bowatte, Garun Hamilton and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respirology (Carlton, Vic.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Dinh S BuiAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0000-0002-4388-784X
Don VicendeseAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Jonathan PhamAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Nur Sabrina IdroseAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0000-0002-7079-3670
Adrian LoweAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Caroline LodgeAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Raisa CassimAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Chamara SenaratnaAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Gayan BowatteAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Garun HamiltonDepartment of Lung, Sleep, Allergy & Immunology, Monash Health, Clayton, Victoria, Australia.
Alan JamesDepartment of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Western, Australia.
Paul ThomasInflammation and Infection Research, Faculty of Medicine, University of New South Wales, New South Wales, Australia.
Richard Wood-BakerSchool of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Peter FrithCollege of Medicine and Public Health, Flinders University, Adelaide, Australia.
Gary AndersonCentre for Lung Health, University of Melbourne, Melbourne, Australia.
Philip M HansbroCentre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, New South Wales, Australia.
Graeme ZoskyUniversity of Tasmania, Hobart, Tasmania, Australia.
George WashkoHarvard Medical School, Harvard University, Boston, Massachusetts, USA.
Michael J AbramsonSchool of Preventive Medicine, Monash University, Melbourne, Australia.
Rosa FanerCentro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
Alvar AgustiCentro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
Jennifer PerretAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
E Haydn WaltersAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Shyamali C DharmageAllergy and Lung Health Unit, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0000-0001-6063-1937

Funding

Australian NHMRC 1101313EU 633212GlaxoSmithKlineHelen MacPherson Smith TrustNational Health and Medical Research Council (NHMRC) 1021275National Health and Medical Research Council (NHMRC) 299901Royal Hobart Hospital Research FoundationUniversity of Melbourne; Clifford Craig Medical Research Trust of TasmaniaVictorian, Queensland & Tasmanian Asthma Foundations
6 · The paper itself

Abstract

BACKGROUND AND

objectiveIdentifying impaired lifetime lung function trajectories and their underlying biological pathways is key to characterising the preclinical phase of COPD (Pre-COPD) and its progression. However, this is challenging in practice as repeated spirometry measurements from childhood are rarely available. We investigated potential blood biomarkers associated with pre-COPD trajectories.

methodsThe Tasmanian Longitudinal Health Study has unique lung function data from 7 to 53 years, from which lifetime FEV

resultsAmong six FEV

conclusionThis is the first study to show that established COPD biomarkers are already active during the pre-COPD phase and could distinguish pre-COPD lung function trajectories. Biomarkers, particularly together with clinical history, may have the potential to identify those at risk and optimise management of both Pre-COPD and COPD.

Indexed as

BiomarkersLungPulmonary Disease, Chronic ObstructiveAdolescentChildC-Reactive ProteinCytokinesDisease ProgressionFemaleForced Expiratory VolumeHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesRespiratory Function TestsBiomarkersC-Reactive ProteinCytokinesUteroglobinbiomarkerCOPDlung function trajectoryobstructionpre‐COPD

Identifiers

PMID42442716
PMCPMC13634688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.