Evidence map›Paper›PMID 42442528›Full record

ArticleChest2026

The ARDS, Pneumonia, and Sepsis Consortium: Rationale, Design, and Feasibility of a National Platform for Phenotyping Critical Illness Syndromes.

Wesley H Self, Carolyn S Calfee, Samuel M Brown, Marc Moss, Lorraine B Ware, Robert C Hyzy, Nuala J Meyer, John P Reilly, Michael O Harhay, Michael G S Shashaty and 73 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06521502 (The ARDS, Pneumonia, and Sepsis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06521502 recruitingnot on this map

The ARDS, Pneumonia, and Sepsis (APS) Consortium: A Prospective Observational Study to Evaluate Phenotypes

TypeobservationalSponsorVanderbilt University Medical CenterRan2024 to 2029Enrolled4,000ConditionsARDS, Sepsis, PneumoniaArmsBlood collection, Urine Collection, Nasal, oral, and rectal swabs, Stool collection, Heat Moisture Exchange Filter collection
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

83 authors.

Wesley H SelfVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN. Electronic address: wesley.self@vumc.org.
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Franscico, San Francisco, CA.
Samuel M BrownDepartment of Pulmonary and Critical Care Medicine, Intermountain Medical Center, Salt Lake City, UT.
Marc MossDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO.
Lorraine B WareDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN; Department Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN; University of Michigan, Ann Arbor, MI.
Robert C HyzyUniversity of Michigan, Ann Arbor, MI.
Nuala J MeyerPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
John P ReillyDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA.
Michael O HarhayDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA.
Michael G S ShashatyDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA.
Danielle K SandsmarkDivision of Neurocritical Care, Department of Neurology, University of Pennsylvania, Philadelphia, PA.
Catherine L AuriemmaDivision of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA; Palliative and Advanced Illness Research Center, University of Pennsylvania, Philadelphia, PA.
Tiffanie K JonesUniversity of Pennsylvania, Philadelphia, PA.
Hallie C PrescottDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI.
Robert P DicksonDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI; Weil Institute for Critical Care Research and Innovation, University of Michigan, Ann Arbor, MI.
Kristine NelsonUniversity of Michigan, Ann Arbor, MI.
Jakob I McSparronDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
Madeline LaginaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
Scott J DenstaedtDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
Andrew J AdmonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI; Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI.
Bhakti K PatelSection of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL.
Krysta S WolfeDepartment of Medicine, University of Chicago, Chicago, IL.
R Duncan HiteUniversity of Cincinnati College of Medicine, Cincinnati, OH.
Kristin M HudockDivision of Pulmonary, Sleep, and Critical Care Medicine, Department of Medicine, University of Cincinnati, Cincinnati, OH.
Julie A BastaracheDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
Tatsuki KoyamaVanderbilt University Medical Center, Nashville, TN.
V Eric KerchbergerDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.
E Wesley ElyVanderbilt University Medical Center, Nashville, TN; Tennessee Valley Veteran's Affairs Geriatric Research Education Clinical Center, Nashville, TN.
James C JacksonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Pratik SinhaDepartment of Anesthesiology, Washington University in Saint Louis School of Medicine, Saint Louis, MO.
Philip A MuddDepartment of Emergency Medicine, Washington University in Saint Louis School of Medicine, Saint Louis, MO.
Bryan D KraftDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University in Saint Louis, Saint Louis, MO.
Richard D FremontMeharry Medical College, Nashville, TN.
Rajbir SinghMeharry Medical College, Nashville, TN.
Neil R AggarwalDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO.
Sarah E JolleyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO.
Ellen L BurnhamUniversity of Colorado School of Medicine, Aurora, CO.
Rafaela A MantelliDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO.
William J JanssenDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz, Aurora, CO.
Camille M MooreCenter for Genes, Environment and Health, National Jewish Health, Denver, CO.
Ivor S DouglasWestchester Medical Center Health, New York Medical College, Valhalla, NY.
Ryan PetersonUniversity of Iowa, Iowa City, IA.
Ithan D PeltanDepartment of Pulmonary and Critical Care Medicine, Intermountain Medical Center, Salt Lake City, UT.
Christina E BarkauskasDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, Duke University, Durham, NC.
Elias H PrattDuke University School of Medicine, Durham, NC.
Estelle S HarrisUniversity of Utah, Salt Lake City, UT.
Daniel O ScharfsteinDivision of Biostatistics, Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City, UT.
Dale M NeedhamDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD.
Sarina K SahetyaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD.
Ann M ParkerDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Outcomes After Surgery and Critical Illness Research Group, Johns Hopkins University School of Medicine, Baltimore, MD.
Theodore J IwashynaJohns Hopkins University, Baltimore, MD.
Kevin ShenderovDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Michael A MatthayDepartment of Anesthesia, University of California, San Franscico, San Francisco, CA; Cardiovascular Research Institute, University of California, San Franscico, San Francisco, CA; Department of Medicine, University of California, San Franscico, San Francisco, CA.
Narges Alipanah-LechnerDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Franscico, San Francisco, CA.
Liam MageeUniversity of California, San Franscico, San Francisco, CA.
Tal ShwartzmanUniversity of California, San Franscico, San Francisco, CA.
Chelsea LinUniversity of California, San Franscico, San Francisco, CA.
Melanie F WeingartDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California, San Franscico, San Francisco, CA.
Charles R LangelierDivision of Infectious Diseases, University of California, San Franscico, San Francisco, CA.
Olivia ChaoUniversity of California, San Franscico, San Francisco, CA.
Carolyn M HendricksonZuckerberg San Francisco General Hospital, University of California, San Franscico, San Francisco, CA.
Lucy Z KornblithZuckerberg San Francisco General Hospital, University of California, San Franscico, San Francisco, CA.
Suzanna ChakZuckerberg San Francisco General Hospital, University of California, San Franscico, San Francisco, CA.
Kim BardillonZuckerberg San Francisco General Hospital, University of California, San Franscico, San Francisco, CA.
Kimberly Herrera RodriguezZuckerberg San Francisco General Hospital, University of California, San Franscico, San Francisco, CA; University of California, San Franscico, San Francisco, CA.
Angela J RogersDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA.
Andrew R MooreDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA.
Joseph E LevittDivision of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA.
Rosemary VojnikStanford University, Stanford, CA.
Cynthia PerezStanford University, Stanford, CA.
Christopher J LindsellDuke University, Durham, NC.
Matthew S ShotwellDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
Bryan S BletteDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
Brant W ImhoffDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
Todd W RiceVanderbilt University Medical Center, Nashville, TN.
Jillian P RhoadsVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN.
Kelsey N WomackVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN.
Alyssa R MerkelVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN.
Lillian N AhmadVanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN.
Xiaoli ZhaoNational Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD.
Ingrid Espinoza GrandonDivision of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Michelle Ng GongDivision of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
ARDS, Pneumonia, and Sepsis Consortium

Funding

Expediting the Sharing of APS Consortium Specimens and Data Amidst Expanded OperationsU01HL168478 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Christopher J. Lindsell, Wesley H Self · 2023 to 2026
$23.0M
The MUltidimenSional phenotyping In Critical care (MUSIC) Consortium: A pathway to precision medicine at the bedsideU01HL168412 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2023 to 2026
$1.9M
Colorado APS Clinical CenterU01HL168145 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Neil Raj Aggarwal, William Janssen · 2023 to 2026
$1.8M
Phenotyping ARDS, Pneumonia, and Sepsis over time to elucidate shared and distinct trajectories ofillness and recoveryU01HL168419 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Michael Oscar Harhay, Nuala Jennings Meyer · 2023 to 2026
$1.8M
Molecular Phenotyping of ARDS, Pneumonia, and Sepsis using Latent Class Analysis and Metagenomic SequencingU01HL168415 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carolyn Calfee · 2023 to 2026
$1.8M
Great Lakes Clinical Center of the Acute Respiratory Distress Syndrome, Pneumonia and Sepsis (APS) ConsortiumU01HL168308 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Robert Pickett Dickson, Robert C Hyzy · 2023 to 2026
$1.8M
The Intermountain West-Atlantic Center (InterACT) for the APS Phenotyping ConsortiumU01HL168416 · NHLBI · IHC HEALTH SERVICES, INC. · PI Christina Eleanor Barkauskas, Samuel Morris Brown · 2023 to 2026
$1.8M
NHLBI NIH HHS U01 HL168145NHLBI NIH HHS U01 HL168308NHLBI NIH HHS U01 HL168412NHLBI NIH HHS U01 HL168415NHLBI NIH HHS U01 HL168416NHLBI NIH HHS U01 HL168419NHLBI NIH HHS U01 HL168478
6 · The paper itself

Abstract

backgroundTo enhance biological understanding of ARDS, pneumonia, and sepsis and to accelerate therapeutic development in these areas, the National Institutes of Health developed the ARDS, Pneumonia, and Sepsis (APS) Consortium. RESEARCH QUESTION: Is the APS Consortium study rapidly generating data and biospecimens from a large cohort of critically ill adults with ARDS, pneumonia, and sepsis that will facilitate phenotyping of these syndromes? STUDY DESIGN AND

methodsThe APS Consortium Phenotyping Study is a multicenter, longitudinal, prospective, observational cohort study aimed at enrolling 4,000 critically ill adults with ARDS, pneumonia, sepsis, or a combination thereof over 4 years. Data and biospecimens are collected to characterize many aspects of each participant's chronic health, acute illness, and long-term recovery to facilitate phenotyping, that is, subclassifying ARDS, pneumonia, and sepsis into precise biologically based subsets with shared pathophysiologic characteristics. Feasibility of the study was assessed by evaluating the first 1,000 participants in terms of recruitment pace, participant characteristics, biospecimen collection, and proportion with confirmed ARDS, pneumonia, and sepsis based on expert adjudication.

resultsThe first 1,000 participants were recruited ahead of schedule in < 13 months. Median age was 64 years, 75% received vasopressors, 50% received invasive mechanical ventilation, and 25% died in the hospital within 4 weeks of enrollment. Biospecimen collection rates were high, with 99% of participants with blood samples, 98% with upper respiratory swabs, 37% with lower respiratory samples, 80% with urine samples, and 65% with gastrointestinal samples. Expert adjudication resulted in 40% classified with ARDS, 52% classified with pneumonia, and 89% classified with sepsis.

interpretationThe APS Consortium Phenotyping Study is producing a cohort of critically ill adults with ARDS, pneumonia, and sepsis with high severity of disease and a rich set of data and biospecimens. The study will continue to full enrollment of 4,000 participants. CLINICAL

trial registrationClinicalTrials.gov; No.: NCT06521502; URL: www. CLINICALTRIALS: gov.

Indexed as

acute respiratory distress syndromecritical carephenotypepneumoniaprecision medicinerecoverysepsis

Identifiers

PMID42442528
PMCPMC13507944

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.