Evidence map›Paper›PMID 42442371›Full record

ArticleThe Lancet. Global health2026

Exploration of the vein to vein blood transfusion system in three Kenyan counties: a qualitative study.

Linda S Barnes, Jennifer Makin, Jose R Paiz, Jana Macleod, Cindy Mical Makanga, Tecla Kivuli Chelagat, Alejandro Munoz-Valencia, Ejemai Eboreime, Robert Kamu Kaburu, Abdirahman Musa and 7 more

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Article in The Lancet. Global health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

17 authors.

Linda S BarnesLinda S Barnes Consulting, Seattle, WA, USA; University of Pittsburgh, Pittsburgh, PA, USA; Strathmore University, Nairobi, Kenya. Electronic address: lbarnes23@gmail.com.
Jennifer MakinUniversity of Pittsburgh, Pittsburgh, PA, USA.
Jose R PaizUniversity of Pittsburgh, Pittsburgh, PA, USA.
Jana MacleodStrathmore University, Nairobi, Kenya; Kenyatta University, Nairobi, Kenya.
Cindy Mical MakangaStrathmore University, Nairobi, Kenya.
Tecla Kivuli ChelagatStrathmore University, Nairobi, Kenya.
Alejandro Munoz-ValenciaUniversity of Pittsburgh, Pittsburgh, PA, USA.
Ejemai EboreimeDalhousie University, Halifax, NS, Canada.
Robert Kamu KaburuStrathmore University, Nairobi, Kenya.
Abdirahman MusaStrathmore University, Nairobi, Kenya.
Carolyne NjokiAga Khan University, Nairobi, Kenya.
Cavin Otieno OpiyoStrathmore University, Nairobi, Kenya.
Kristina E RuddUniversity of Pittsburgh, Pittsburgh, PA, USA.
Mark YazerUniversity of Pittsburgh, Pittsburgh, PA, USA.
Bopaya BidandaUniversity of Pittsburgh, Pittsburgh, PA, USA.
Juan Carlos PuyanaUniversity of Pittsburgh, Pittsburgh, PA, USA; Royal College of Surgeons, Dublin, Ireland.
Pratap KumarStrathmore University, Nairobi, Kenya; University College London, London, UK.

Funding

The BLOODSAFE Data Coordinating Center: A Data Center for More SafeTransfusions in Sub-Saharan AfricaU24HL151541 · NHLBI · UNIVERSITY OF MINNESOTA · PI REILLY, CAVAN S. · 2020 to 2025
$5.5M
Pathways for innovation in Blood Transfusión Systems in Kenya (PITS Kenya)UH3HL151595 · NHLBI · STRATHMORE UNIVERSITY · PI KIVULI, TECLA CHELAGAT, KUMAR, PRATAP · 2022 to 2025
$2.4M
Pathways for innovation in Blood Transfusión Systems in Kenya (PITS Kenya)UG3HL151595 · NHLBI · STRATHMORE UNIVERSITY · PI KUMAR, PRATAP, PUYANA, JUAN CARLOS · 2020 to 2021
$1.0M
Enhancing Blood Donation at Schools and Beyond: An Implementation Science StudyUG3HL152189 · NHLBI · MALAWI BLOOD TRANSFUSION SERVICE · PI HOSSEINIPOUR, MINA CHRISTINE, MBAYA, BRIDON · 2020 to 2021
$826k
Development and evaluation of community-based approaches and donor care intervention models for improving availability and safety of blood for the management of severe anemia in GhanaUG3HL151599 · NHLBI · UNIVERSITY OF GHANA · PI ASAMOAH-AKUOKO, LUCY, DEI-ADOMAKOH, YVONNE · 2020 to 2021
$470k
NHLBI NIH HHS U24 HL151541NHLBI NIH HHS UG3 HL151595NHLBI NIH HHS UG3 HL151599NHLBI NIH HHS UG3 HL152189NHLBI NIH HHS UH3 HL151595
6 · The paper itself

Abstract

backgroundSevere shortages of blood for transfusion are a persistent global health crisis, with the burden disproportionately concentrated in low-income countries. Diverse stakeholder perspectives on blood availability might inform improvements. We aimed to use a comprehensive approach to identify the challenges, facilitators, and innovations within the blood transfusion continuum (BTC) in three different Kenyan settings.

methodsIn this qualitative study, we interrogated the BTC in Siaya, Nakuru, and Turkana counties as part of the Pathways for Innovation in Blood Transfusion Systems in Kenya (PITS Kenya) mixed methods research study. We used purposive sampling, and through interviews and focus group discussions, we solicited perspectives about the challenges, barriers, and facilitating features of the BTC, including any innovations, from health-care workers, hospital administration, government officials, transfused patients, and blood donors aged 18 years and older, who were familiar with the BTC, from Aug 5, 2021, to May 9, 2022. We thematically analysed interview and discussion transcriptions using an iterative approach to achieve saturation of the thematic content. The findings were validated via member checking and stakeholder meetings in Nairobi that included research participants, non-governmental organisations, and Kenyan health authorities.

findings197 participants (84 [43%] female and 113 [57%] male) participated in 74 interviews (76 participants) and 18 focus group discussions (121 participants). Seven themes emerged: (1) massive shortages of blood, (2) mismatches between where blood is stored and where patients need it, (3) reliance on family replacement donors, (4) delays in patient care, (5) stresses to the health-care system and workforce hardship, (6) variable knowledge and attitudes towards blood donation and transfusion, and (7) limited resources. Facilitation of blood transfusion involved local champions through self-organised and community engagement. Innovations advocated for improved resource allocation, education, and collaborative efforts.

interpretationThis study identified BTC challenges, facilitators, and innovations. The participants described the BTC as fragmented in these settings. The most poignant findings revealed how the lack of blood availability caused profound stress on the health system, contributing to delays, inefficiencies, and worry for patient wellbeing. Innovations encouraged collective stewardship and governance of the BTC, bridging communities and health-care facilities.

fundingThe US National Institutes of Health National Heart, Lung, and Blood Institute.

Indexed as

Blood DonorsBlood TransfusionAdultFemaleFocus GroupsHumansKenyaMaleMiddle AgedQualitative ResearchResource-Limited Settings

Identifiers

PMID42442371
PMCPMC13653559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.