Evidence map›Paper›PMID 42442015›Full record

Trial reportAddictive behaviors2026

A randomized controlled trial examining the effects of human models in e-cigarette advertisements and e-cigarette use among susceptible young adults.

Donghee Nicole Lee, Ian Pagano, Darren Mays, Theodore L Wagener, Elise M Stevens

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Addictive behaviors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Donghee Nicole LeePopulation Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI, United States. Electronic address: nlee@cc.hawaii.edu.
Ian PaganoPopulation Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI, United States.
Darren MaysCenter for Tobacco Research, The Ohio State University James Comprehensive Cancer Center, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States.
Theodore L WagenerCenter for Tobacco Research, The Ohio State University James Comprehensive Cancer Center, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, United States.
Elise M StevensDepartment of Population and Quantitative Health Sciences, Division of Preventive and Behavioral Medicine, UMass Chan Medical School, Worcester, MA, United States.

Funding

Young Adults Responses to E-Cigarette Advertisement Features and the Effects of Restricting Features on Tobacco UseR00DA046563 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STEVENS, ELISE MARIE · 2021 to 2023
$914k
Identifying and examining the effects of source and presentation on responses to electronic cigarette public education messages in young adult vapers and non-vapersR00CA281094 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Donghee Nicole Lee · 2025 to 2026
$498k
Identifying and examining the effects of source and presentation on responses to electronic cigarette public education messages in young adult vapers and non-vapersK99CA281094 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEE, DONGHEE NICOLE · 2024 to 2025
$289k
NCI NIH HHS K99 CA281094NCI NIH HHS R00 CA281094NIDA NIH HHS R00 DA046563
6 · The paper itself

Abstract

backgroundThe tobacco industry's aggressive marketing has driven e-cigarette use prevalence in young adults. Restricting appealing features - human models - from industry advertisements may reduce product appeal and discourage e-cigarette use in younger populations.

designWe conducted a 2-arm parallel design randomized trial to examine the effects of regulating e-cigarette advertisements by removing human models and collected self-reported measures at 0, 4, 12, and 24 weeks.

interventionSusceptible young adults (N = 185; Mage = 22.5) were randomly assigned to the regulated or unregulated advertisement conditions and viewed an online magazine containing an e-cigarette advertisement every week for 24 weeks during the study. MEASURES: The primary outcome was self-reported e-cigarette harm perceptions and use intentions, and salivary cotinine results assessed at 4, 12, and 24 weeks.

resultsPath analyses showed a sequential pathway, with harm perceptions partially mediating the relationship between viewing the unregulated (humans present) advertisement condition and increased intentions to use e-cigarettes (SRMR = 0.074, AGFI = 0.902, NNFI = 0.944).

conclusionsThe inclusion of human models in e-cigarette advertisements may reduce perceived e-cigarette harms over time, potentially increasing use intentions among susceptible young adults. Findings can inform the FDA and public advocacy initiatives to strengthen marketing regulations of tobacco products and reduce the impact of industry marketing on young people.

Indexed as

AdvertisingElectronic Nicotine Delivery SystemsVapingAdolescentAdultCotinineFemaleHumansIntentionMaleMedia ExposureSalivaYoung AdultCotinineE-cigarette advertisementsTobacco marketing regulationYoung adults

Identifiers

PMID42442015
PMCPMC13451013

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.