Evidence map›Paper›PMID 42441982›Full record

ArticlePhysiological genomics2026

Multiomic characterization of DNA released after airway exposure to allergens and nanoparticles reveals selective export of repetitive and fragile site DNA.

Kayla Law, Yotesawee Srisomboon, Koji Iijima, Christopher Faulk, Hirohito Kita, Scott M O'Grady

Abstract read
In one paragraph

Article in Physiological genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kayla LawDepartment of Animal Science, University of Minnesota, St. Paul, Minnesota, United States.ORCID 0000-0003-3560-8465
Yotesawee SrisomboonDepartment of Animal Science, University of Minnesota, St. Paul, Minnesota, United States.
Koji IijimaDivision of Allergic Diseases, Department of Medicine, Mayo Clinic, Scottsdale, Arizona, United States.
Christopher FaulkDepartment of Animal Science, University of Minnesota, St. Paul, Minnesota, United States.ORCID 0000-0002-9749-9658
Hirohito KitaDivision of Allergic Diseases, Department of Medicine, Mayo Clinic, Scottsdale, Arizona, United States.ORCID 0000-0002-6854-2936
Scott M O'GradyDepartment of Animal Science, University of Minnesota, St. Paul, Minnesota, United States.ORCID 0000-0002-0474-5451

Funding

Mechanisms of IL-33 secretion in allergic diseasesR01AI128729 · NIAID · MAYO CLINIC ROCHESTER · PI Hirohito Kita, SCOTT M. O'GRADY · 2017 to 2026
$5.6M
Allergen-induced extracellular DNA in type 2 immunityR01AI169530 · NIAID · MAYO CLINIC ARIZONA · PI KITA, HIROHITO, O'GRADY, SCOTT M. · 2022 to 2025
$3.2M
Allergen-induced IL-33 release by the airway epitheliumR01HL110539 · NHLBI · MAYO CLINIC ROCHESTER · PI KITA, HIROHITO, O'GRADY, SCOTT M. · 2011 to 2014
$2.0M
HHS | National Institutes of Health (NIH) R01AI128729HHS | National Institutes of Health (NIH) R01AI169530Minnesota Agriculture Experiment Station AES0016134NHLBI NIH HHS R01 HL110539NIAID NIH HHS R01 AI128729NIAID NIH HHS R01 AI169530
6 · The paper itself

Abstract

Allergen and nanoparticle exposure generate reactive oxygen species (ROS) that endanger genome integrity, yet airway epithelial cells survive repeated exposures. Here we show that environmental allergens from

Indexed as

AllergensDNANanoparticlesRepetitive Sequences, Nucleic AcidAlternariaAnimalsEpithelial CellsExtrachromosomal DNAHumansMiceMultiomicsOxidative StressPolyethyleneimineAllergensDNAExtrachromosomal DNAPolyethyleneimineallergensallergic airway inflammationgenome integritygenomic damagenanoparticles

Identifiers

PMID42441982
PMCPMC13504713

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.