ReviewJBRA assisted reproduction2026
Chemotherapy-Induced Infertility: Mechanisms, Risk Factors, and Fertility Preservation Strategies in Cancer Patients.
Review in JBRA assisted reproduction, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemotherapy remains a cornerstone of cancer treatment, effectively targeting rapidly dividing cancer cells, yet its systemic effects often extend to healthy reproductive cells, resulting in temporary or permanent infertility. This review explores the mechanisms by which chemother-apy impairs fertility in both men and women, focusing on the damage to ovarian follicles and spermatogenesis. Key factors influencing fertility outcomes include the type and dosage of chemotherapy drugs, patient age, and pre-existing reproductive health. Alkylating agents, such as cyclophosphamide, and platinum-based drugs, like cisplatin, pose the highest risk of gonad-otoxicity, while other agents exhibit milder, often reversible effects. Fertility preservation op-tions such as oocyte and embryo freezing for women, sperm banking for men, and emerging techniques like ovarian and testicular tissue cryopreservation offer hope for maintaining re-productive potential. The psychological burden of infertility and the promising yet complex role of nanoparticles in reproductive medicine are also discussed. By synthesizing current research, this review underscores the need for personalized fertility counseling and advanced preserva-tion strategies to balance cancer treatment efficacy with reproductive goals.
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Registered trials
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