Evidence map›Paper›PMID 42441870›Full record

ArticleChemMedChem2026

Design and Synthesis of Novel Imidazo[4,5-c]pyridine Derivatives, Evaluation of Their Activity Against Hepatitis C Virus and In Silico Prediction of Their Binding Mode to NS4B Protein.

Eftychia Karampella, George Mpekoulis, Maria Georgiou, Iris Kolida, Katerina I Kalliampakou, Eirini P Kollia, Eleni V Mikropoulou, Maria Halabalaki, Christos T Chasapis, Niki Vassilaki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eftychia KarampellaLaboratory of Medicinal Chemistry, Division of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
George MpekoulisMolecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece.
Maria GeorgiouLaboratory of Medicinal Chemistry, Division of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Iris KolidaMolecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece.
Katerina I KalliampakouMolecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece.
Eirini P KolliaMolecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece.
Eleni V MikropoulouDivision of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-4033-5580
Maria HalabalakiDivision of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Christos T ChasapisLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.
Niki VassilakiMolecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece.
Nikolaos LougiakisLaboratory of Medicinal Chemistry, Division of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of suitably substituted imidazo[4,5-c]pyridine derivatives was synthesized, starting from 4-amino-2-chloropyridine, and their antiviral activity against hepatitis C virus (HCV) genotype 1b (GT1b) was evaluated in Huh5.2 replicon cells. Some of the N

Indexed as

Antiviral AgentsDrug DesignHepacivirusImidazolesPyridinesViral Nonstructural ProteinsBinding SitesHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntiviral AgentsImidazolesNS4B protein, flavivirusPyridinesViral Nonstructural Proteinsantiviral agentsdrug designhepatitis C virus (HCV)homology modelingimidazopyridinemolecular dockingNS4B protein

Identifiers

PMID42441870
PMCPMC13363010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.