Evidence map›Paper›PMID 42441406›Full record

ArticleCell reports2026

Sustained AMPAR expression in CA3 neurons may mediate neuroprotection following FLASH-RT.

Louis V Kunz, Aymeric Almeida, Michèle Knol, Benoît Petit, Enikö A Kramár, Marcelo A Wood, Charles L Limoli, Marie-Catherine Vozenin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Louis V KunzRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland; LiRR - Laboratory of Innovation in Radiobiology Applied to Radiotherapy/Faculty of Medicine/University of Geneva, Geneva, Switzerland.
Aymeric AlmeidaRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland; LiRR - Laboratory of Innovation in Radiobiology Applied to Radiotherapy/Faculty of Medicine/University of Geneva, Geneva, Switzerland.
Michèle KnolRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland; LiRR - Laboratory of Innovation in Radiobiology Applied to Radiotherapy/Faculty of Medicine/University of Geneva, Geneva, Switzerland.
Benoît PetitRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland; LiRR - Laboratory of Innovation in Radiobiology Applied to Radiotherapy/Faculty of Medicine/University of Geneva, Geneva, Switzerland; Radiation Oncology Laboratory, University Hospital and University of Lausanne, Lausanne, Switzerland.
Enikö A KramárDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Charles L LimoliDepartment of Radiation Oncology, University of California, Irvine, Irvine, CA 92697, USA.
Marie-Catherine VozeninRadiotherapy and Radiobiology Sector, Radiation Therapy Service, University Hospital of Geneva, Geneva, Switzerland; LiRR - Laboratory of Innovation in Radiobiology Applied to Radiotherapy/Faculty of Medicine/University of Geneva, Geneva, Switzerland; Radiation Oncology Laboratory, University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: marie-catherine.vozenin@unige.ch.

Funding

Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
Improving pediatric brain tumor treatments using FLASH radiotherapyR01CA254892 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Charles Limoli · 2021 to 2026
$2.5M
NCI NIH HHS P01 CA244091NCI NIH HHS R01 CA254892
6 · The paper itself

Abstract

To elucidate the early mechanisms underlying the long-term neuroprotective effect of FLASH-RT in the normal brain, spatial transcriptomics (Nanostring) were performed after whole-brain irradiation of C57BL/6J mice with either 1 or 3 fractions of 10 Gy at 5.6 × 10

Indexed as

CA3 Region, HippocampalNeuronsNeuroprotectionReceptors, AMPAAnimalsDentate GyrusMaleMiceMice, Inbred C57BLReceptors, AMPAAMPARCA3CalciumCognitionCP: neuroscienceFLASHGlutamate ReceptorHippocampusNeuronRadiotherapyTranscriptomics

Identifiers

PMID42441406
PMCPMC13584352

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.