ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Longitudinal changes in DTI-ALPS and choroid plexus volume relative to CSF biomarkers during lecanemab treatment in mild cognitive impairment: A pilot study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Anti-Amyloid Monoclonal Antibodies in Early Alzheimer Disease: Lecanemab and Donanemab.Neurology international · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLecanemab improves cerebrospinal fluid (CSF) biomarkers, but whether magnetic resonance imaging (MRI) proxies of CSF-interstitial fluid (ISF) exchange improve is unknown.
methodsThis was a single-center prospective pilot (
resultsCSF Aβ42 and Aβ42/40 increased and tau phosphorylated at threonine 181 (p-tau181) decreased at 6 and 12 months (all DISCUSSION: The ALPS index and ChP volume may be insufficient as stand-alone surrogate endpoints over 12 months. These findings suggest exploring complementary strategies targeting CSF-ISF exchange and clearance pathways and warrant larger controlled longitudinal studies. CLINICAL TRIAL REGISTRATION INFORMATION: Not applicable (observational study).
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