ArticleFrontiers in toxicology2026
A comprehensive safety evaluation of approved 2'-fucosyllactose for human nutritional applications in China.
Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: 2'-Fucosyllactose (2'-FL), as a significant human milk oligosaccharide, plays a crucial role in infant formula products. This study aims to provide a scientific basis for the safe application of 2'-FL by systematically evaluating its physicochemical properties, production strain safety, toxicological data, and population exposure levels. Methods: This study characterizes the physicochemical properties of 2'-FL, evaluates the safety of its production strain, and conducts a series of toxicological assessments, including an acute oral toxicity test, genotoxicity tests, a 90-day subchronic toxicity test, and a teratogenicity test. Additionally, an exposure assessment of 2'-FL was conducted by integrating usage level data with food consumption data. Result: The production strain for 2'-FL is recognized as safe, and all the results of toxicological experiments show negative or no observed adverse effects. Exposure assessment data further confirm that infant and young child populations exposed to 2'-FL remain within established safety limits under the specified usage levels. Consequently, the use of 2'-FL as a food ingredient is considered safe. Discussion: The safety and technological necessity of 2'-FL constitute the scientific basis for its approval as a novel nutritional additive authorized for use in infant formula products.
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