ArticleACG case reports journal2026
Sequential Biologic, Small-Molecule, and GLP-1 Analogue Therapy in Postcolectomy Enteritis With High Output Stoma.
Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Postcolectomy enteritis is a rare but serious complication after colectomy for ulcerative colitis. We report the case of a 71-year-old man with acute severe ulcerative colitis who developed steroid-refractory postcolectomy enteritis after subtotal colectomy with end ileostomy. Postoperatively, he experienced persistent high output stoma and ongoing ileal inflammation despite treatment with corticosteroids, infliximab, upadacitinib, and octreotide. Induction therapy with ustekinumab led to gradual endoscopic, histological, and radiological improvement. Off-label use of a glucagon-like peptide-1 analogue was initiated for the management of high output stoma, with subsequent reduction in stoma losses and successful weaning from parenteral nutrition.
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