ArticleJournal of biomedical optics2026
Multimodal imaging platform for rapid non-destructive evaluation of pancreatic puncture specimens.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Significance: Destructive staining and slow subjective visual inspection remain major limitations in rapid evaluation of biopsy specimens during endoscopic ultrasound-guided fine needle biopsy. Therefore, there is a strong need for a label-free optical imaging approach that enables quantitative specimen assessment while preserving specimen integrity. Aim: A multimodal imaging system integrating hyperspectral and color imaging was developed to acquire images of biopsy specimens without staining or sample preparation. Approach: A hyperspectral on-site evaluation workflow was proposed, integrating hyperspectral imaging and color imaging within a modular platform. Hyperspectral data were analyzed using a support-vector-machine-based segmentation framework for specimen assessment with color images providing reference annotations. No washing or staining is required. Results: Validation on 220 pancreatic biopsy specimens demonstrates accurate non-destructive macroscopic visible core evaluation, achieving an Conclusions: We demonstrate that integrating hyperspectral imaging with computational analysis enables rapid, quantitative, and label-free specimen evaluation, highlighting the potential of biomedical optical systems for intra-procedural specimen assessment.
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