Evidence map›Paper›PMID 42441083›Full record

ArticleDEN open2027

Adverse Pathological Features and Worse Prognosis in Rectal Cancer Compared With Colon Cancer in T1 and T2 Stages.

Shunto Iwasaki, Shin-Ei Kudo, Yuta Kouyama, Katsuro Ichimasa, Shigenori Semba, Yuriko Morita, Yuki Takashina, Tomotaka Takizawa, Yu Nimura, Taishi Okumura and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DEN open, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shunto IwasakiDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Shin-Ei KudoDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Yuta KouyamaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Katsuro IchimasaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Shigenori SembaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Yuriko MoritaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Yuki TakashinaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Tomotaka TakizawaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Yu NimuraDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Taishi OkumuraDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Kenta NakaharaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Yasuharu MaedaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Noriyuki OgataDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Takemasa HayashiDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Naruhiko SawadaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Toshiyuki BabaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Tetsuo NemotoDepartment of Diagnostic Pathology and Laboratory Medicine Showa Medical University Northern Yokohama Hospital Kanagawa Japan.
Masashi MisawaDigestive Disease Center Showa Medical University Northern Yokohama Hospital Kanagawa Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Emerging endoscopic techniques are expanding opportunities for minimally invasive therapy in early colorectal cancers (CRCs). Data regarding the clinicopathological features and outcomes of colon versus rectal cancers in Tis, T1, and T2 stages remain limited. This study evaluates and compares these two entities to clarify their oncologic differences. Methods: We retrospectively analyzed patients with pTis-T2 CRCs treated by endoscopic or surgical resection at a single Japanese center between 2001 and 2022. Tumor location was classified as rectum (Ra, Rb) or colon (cecum to RS). Clinical variables (sex and age), pathological features (tumor size, differentiation, lymphatic invasion [Ly], vascular invasion [V], and tumor budding), and recurrence and metastasis rates were compared according to tumor location. Results: The proportion of rectal cancer rose with invasion depth, from 16.2% (271/1673) in Tis to 18.5% (248/1337) in T1 and 26.4% (178/675) in T2 ( Conclusions: Rectal cancers demonstrate more aggressive features and higher recurrence rates than colon cancers. Consequently, these patients require more stringent therapeutic approaches and rigorous postoperative surveillance, even in early stages. Trial Registration: Umin Clinical Trials Registry, UMIN 000042622.

Indexed as

rectal cancerrecurrenceT1 colorectal cancerT2 colorectal cancerTis colorectal cancer

Identifiers

PMID42441083
PMCPMC13334210

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.