ReviewCureus2026
Clinical Outcomes of Regenerative Orthobiologic Treatments in Hip Avascular Necrosis: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hip avascular necrosis is an unstable disease that mostly affects younger patients and is likely to cause collapse of the femoral head, eventually resulting in total hip arthroplasty in spite of efforts put into hip-preservation therapy. The use of regenerative orthobiologic therapies, such as bone marrow-derived cell therapies and platelet-rich plasma, is becoming more popular as it may improve biological repair and retard disease progression. This review evaluated the clinical outcomes of regenerative orthobiologic treatments in hip avascular necrosis, with a focus on conversion to total hip arthroplasty. A systematic review and meta-analysis were conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. PubMed, Scopus, and the Virtual Health Library were searched from inception to December 2025. Comparative studies involving adult patients treated with regenerative orthobiologics were included. The primary outcome was conversion to total hip arthroplasty, which was evaluated with the help of a random-effects model with risk ratios and 95% confidence intervals. Thirteen studies were included. The primary analysis of cell-based therapies demonstrated a significant reduction in total hip arthroplasty conversion (RR 0.53, 95% CI 0.32-0.86) with moderate heterogeneity (I
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Registered trials
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