ArticleJournal of veterinary research2026
Novel SNPs in the leptin gene: implications for growth performance in cultured European sea bass
Article in Journal of veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Leptin, a class I helical cytokine, regulates growth, appetite, energy homeostasis and reproductive functions in fish. The leptin gene ( Material and Methods: This study investigated variations in the Results: Twelve novel single-nucleotide polymorphisms (SNPs) were identified in the first and second introns and the third exon of the gene, including a non-synonymous third exon variant (g.11004767C>T) causing an arginine-to-tryptophan substitution. This locus was significantly associated with multiple growth traits, including total and fillet weights and standard, body and post-anal lengths (P-value < 0.05). Analysis revealed two haploblocks; block 1 having four haplotypes (GCG, GTG, ACA and GTA), with GTA associated with the highest total and fillet weights and body length measurements (P-value < 0.01). Block 2 comprised three haplotypes (AG, GG and AA), where AG carriers exhibited superior growth to GG and AA carriers (P-value < 0.01). Conclusion: These findings indicate that
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