ArticleVeterinary record open2026
OATP1A2 mRNA downregulation in canine hepatocellular carcinoma.
Article in Veterinary record open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: On gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) magnetic resonance imaging, canine hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA) typically exhibit low and high signal intensities in the hepatobiliary phase, respectively. Reduced transporter protein expression is associated with decreased Gd-EOB-DTPA uptake. However, the specific transporters involved in Gd-EOB-DTPA uptake in canine HCC remain unknown. This exploratory study aimed to assess the mRNA expression of transporters that are downregulated in canine HCC. Methods: For the bioinformatics analysis, an RNA sequencing dataset comprising 14 canine HCC samples and four normal liver samples was obtained from the DDBJ BioProject repository. Differentially expressed genes (DEGs) were evaluated for members of the organic anion transporting polypeptides (OATP1-6) family, multidrug resistance-associated protein 2 (MRP2), bile salt export pump (BSEP), breast cancer resistance protein (BCRP), organic cation transporter 1 (OCT1) and multidrug resistance-associated protein 3 (MRP3) in comparison between HCC and normal liver tissues. Genes with an absolute log-fold change greater than 1 and a nominal Results: In bioinformatics analysis, upregulated DEGs in HCC included OATP3A1/ Conclusion: Downregulation of OATP1A2 is associated with canine HCC and may contribute to reduced Gd-EOB-DTPA uptake.
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