Evidence map›Paper›PMID 42440939›Full record

ArticleJournal of the Endocrine Society2026

Alpha-klotho, insulin resistance, and adiposity among older adults.

Anam Ahmad, Michelle Shardell, Rita Rastogi Kalyani, Richard D Semba, Braxton D Mitchell, Toshiko Tanaka, Simeon Taylor, Aman Shrestha, Luigi Ferrucci

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In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Anam AhmadDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Michelle ShardellDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID https://orcid.org/0000-0002-5283-2082
Rita Rastogi KalyaniDepartment of Medicine, Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-1530-6884
Richard D SembaWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Braxton D MitchellDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Toshiko TanakaNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.ORCID https://orcid.org/0000-0002-4161-3829
Simeon TaylorDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID https://orcid.org/0000-0001-7500-7854
Aman ShresthaDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.ORCID https://orcid.org/0000-0002-6273-1613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Alpha-klotho is a circulating protein linked to better metabolic and aging-related outcomes. However, alpha-klotho's relationship with insulin resistance, and the role of adiposity, remain unclear, especially among older adults. Objective: To evaluate the association of circulating alpha-klotho with measures of insulin resistance and incident diabetes among older adults and examine whether these relationships differ by body mass index (BMI). Main outcome measures: The primary outcome was Homeostatic Model Assessment for Insulin Diabetes (HOMA-IR). Secondary outcomes were serum fasting glucose and insulin, and incident diabetes. Design setting and participants: This secondary analysis examined associations of alpha-klotho with outcomes among 825 community-dwelling adults aged ≥55 years enrolled in the Invecchiare in Chianti Study, a prospective population-based cohort. Alpha-klotho and outcomes were assessed 3 years after enrollment. We performed BMI-stratified regression analysis, with adjustment for covariates, including measures of glucose and insulin taken at enrollment. Results: Among 370 overweight participants (BMI 25.0-29.9 kg/m Conclusion: Alpha-klotho was positively associated with insulin resistance, but not incident diabetes, among overweight adults. Findings suggest that alpha-klotho may have a context-dependent relationship with insulin resistance, but not incident diabetes.

Indexed as

alpha-klothoHOMA-IRinsulin resistance

Identifiers

PMID42440939
PMCPMC13334091

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.