ArticleRSC advances2026
New insight into the redox activity of niclosamide, an anthelmintic drug, and some of its metabolites. A new perspective on toxicity and detoxification.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Redox activity of niclosamide (NIC) and its metabolites 2-chloro-4-nitroaniline (2CN) and 5-chlorosalicylic acid (5CA) has been comprehensively investigated over a wide pH range. In this work, to gain a better understanding of the electrochemical activity of NIC, its oxidation and reduction have been investigated independently, and the results are compared with those of 2CN, 5CA, and 4-nitroaniline (4NA) (as a model compound). The results show that both oxidation and reduction pathways of NIC are more complex than those of 2CN, 5CA, and 4NA. While the oxidation of the cathodically generated 2-chloro-
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