Evidence map›Paper›PMID 42440858›Full record

ArticleMolecular therapy. Oncology2026

Intramuscular plasmid DNA electroporation sequesters neoantigen-specific CD8

Bianchi Andrea, Esposito Mauro, Giacomelli Tiziano, Esposito Ilaria, Tonini Claudia, Aurisicchio Luigi, Palombo Fabio

Erratum issuedAbstract read
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Bianchi AndreaNeomatrix, Rome, Italy.
Esposito MauroNeomatrix, Rome, Italy.
Giacomelli TizianoNeomatrix, Rome, Italy.
Esposito IlariaNeomatrix, Rome, Italy.
Tonini ClaudiaNeomatrix, Rome, Italy.
Aurisicchio LuigiNeomatrix, Rome, Italy.
Palombo FabioNeomatrix, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA electroporation of neoantigen cancer vaccine is a well-established approach to induce high expression of neoantigens and likely enlarge the immune response that is shaped by the vaccination site influencing T cell trafficking. Using a DNA plasmid vaccine encoding MC38-derived neoantigens, we found that in presence of tumor, the vaccine delivery by muscle electroporation promotes extensive activation of immune-related genes and CD8

Indexed as

“depot effect”intramuscular DNA electroporationneoantigen cancer vaccineT cell immune response

Identifiers

PMID42440858
PMCPMC13334405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.