ReviewReproductive medicine and biology
Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta-Analysis of Randomized Controlled Trials.
Review in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Platelet-Rich Plasma in Recurrent Pregnancy Loss: Toward a Precision Medicine Framework for Biologically Guided Patient Selection.Medical sciences (Basel, Switzerland) · 2026Review
- Commentary Letter to the Editor Regarding Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta-Analysis of Randomized Controlled Trials.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This meta-analysis evaluates the efficacy and safety of intrauterine autologous platelet-rich plasma (PRP) infusion in patients with recurrent implantation failure (RIF). Methods: Following PRISMA guidelines, we systematically searched major databases and included 10 randomized controlled trials (RCTs, Results: PRP infusion significantly improved clinical pregnancy rate (RR = 2.23, 95% CI 1.84-2.69) and live birth rate (RR = 3.74, 95% CI 2.68-5.22) without increasing miscarriage risk. Subgroup analysis indicated that a 0.5 mL PRP volume was as effective as 0.5-1.0 mL, and a notably greater treatment effect was observed in blastocyst transfer cycles compared to cleavage-stage embryo transfers, suggesting potential enhanced benefit in this subgroup. Conclusion: Intrauterine PRP infusion is an effective and safe treatment for RIF. The findings on dose equivalence and differential efficacy by embryo stage offer valuable insights for optimizing clinical application.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.