ArticleFrontiers in cardiovascular medicine2026
Clinical characteristics and serum HDL-C are associated with adverse prognosis in patients with acute decompensated heart failure with preserved ejection fraction at admission.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aimed to investigate whether clinical characteristics and lipid metabolism parameters are associated with adverse prognosis in patients hospitalized for acute decompensated heart failure (HF) with preserved or reduced left ventricular ejection fraction (LVEF). Methods: This study included 158 patients with chronic heart failure who were hospitalized at the Shaanxi Provincial People's Hospital, Shaanxi, China, between January 2021 and October 2024. They were categorized based on their ejection fraction (EF) into a heart failure preserved EF group [heart failure with preserved ejection fraction (HFpEF); Results: The HFpEF and HFrEF groups showed significant differences in clinical symptoms, including palpitations/angina, cough, sleep at night, lack of appetite, weight loss, abdominal distension, worrying, irritability, decreased libido, and hypertension ( Conclusions: In patients admitted with acute decompensated HF, clinical indicators of congestion, psychological distress, blood pressure load, total cholesterol, and HDL-C are associated with adverse prognosis. Higher HDL-C shows modest but independent prognostic value in acute HF, especially in HFpEF. Further studies are warranted to explore dynamic changes in HDL-C and its role as a metabolic biomarker in HFpEF.
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