Evidence map›Paper›PMID 42440543›Full record

ArticleThe Lancet regional health. Western Pacific2026

Long-term survival in patients discharged alive from hospital following an intensive care unit admission with sepsis or septic shock in Australia and New Zealand: an observational cohort study.

Win Wah, Alexis Paul Poole, Lewis Campbell, Jeremy Cohen, Jamie Cooper, Adam Deane, Anthony Delaney, Glenn Eastwood, Simon Finfer, Craig French and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Western Pacific, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Win WahAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Alexis Paul PooleAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Lewis CampbellIntensive Care, Royal Darwin Hospital, Darwin, Australia.
Jeremy CohenRoyal Brisbane Clinical Unit, Faculty of Health, Medicine and Behavioural Sciences, University of Queensland, Brisbane, Australia.
Jamie CooperAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Adam DeaneIntensive Care Unit, The Royal Melbourne Hospital, Intensive Care, Department of Critical Care, University of Melbourne, Melbourne, Australia.
Anthony DelaneyDivision of Critical Care, George Institute for Global Health, Sydney Medical School, University of Sydney, Sydney, Australia.
Glenn EastwoodAustin Hospital, Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Simon FinferCritical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Craig FrenchIntensive Care (ICU), Western Health, University of Melbourne, Melbourne, Australia.
Kimberley HainesWestern Health, Department of Critical Care, University of Melbourne, Melbourne, Australia.
Naomi HammondCritical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Alisa HigginsAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Carol HodgsonAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Daryl JonesAustin Health, Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Edward LittonIntensive Care Unit, Fiona Stanley Hospital, Perth, Australia.
Zoe McQuiltenMonash Health, Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Ary Serpa NetoAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
David PilcherAlfred Hospital, Australian and New Zealand Intensive Care Society, Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Sandra PeakeDepartment of Intensive Care Medicine at The Queen Elizabeth Hospital, Adelaide, Australia.
Manoj SaxenaSt. George Hospital, The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Kiran ShekarPrince Charles Hospital, University of Queensland, Brisbane, Australia.
Kelly ThompsonGeorge Institute for Global Health, Nepean Blue Mountains Local Health District, Sydney, Australia.
Steven WebbAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, St John of God Healthcare, Melbourne, Australia.
Paul J YoungMedical Research Institute of New Zealand, Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
Andrew A UdyDepartment of Intensive Care & Hyperbaric Medicine, The Alfred Hospital, Australian and New Zealand Intensive Care - Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Data on long-term survival after intensive care unit (ICU) admission for sepsis and septic shock are limited. This study aimed to evaluate survival over five years among critically ill sepsis or septic shock patients discharged alive from hospital. Methods: This retrospective cohort study of adults who survived to hospital discharge after non-elective ICU admission (2018-2024) used Australian and New Zealand Intensive Care Society Adult Patient Database. Sepsis, septic shock, or non-sepsis patients were classified using diagnostic codes and physiological/laboratory criteria during first 24-h of ICU admission. Mixed-effects Cox models with time-varying covariate effects were used, adjusting for demographics, comorbidities, frailty, illness severity, and ICU interventions. Findings: Of 557,538 hospital survivors, 7.3% had sepsis without shock, 11.5% septic shock, and 81.2% non-sepsis conditions. At five-years, unadjusted survival was lowest for septic shock (68.0%, 95% confidence interval/CI = 67.6-68.4%), sepsis without shock (74.2%, 73.7-74.6%), and non-sepsis (78.2%, 78.1-78.3%). After adjustment, hazards ratio/HR for sepsis without shock remained at or below the null relative to non-sepsis; 0-1 year: HR = 0.95, 0.92-0.98; 1-3 years: 0.96, 0.93-1.00; 3-5 years: 1.03, 0.97-1.08, while septic shock showed persistent independent excess mortality; 0-1 year: HR = 1.05,1.03-1.08; 1-3 years: 1.03, 1.00-1.06; and 3-5 years:1.09,1.05-1.14. Major predictors of mortality included age, frailty, comorbidities, and organ support. Interpretation: Septic shock was associated with persistent independent excess mortality over five years after hospital discharge, whereas in sepsis without shock, this was largely explained by pre-existing comorbidity and frailty. Funding: Medical Research Future Fund.

Indexed as

Hospital survivorsIntensive care unit admissionLong-term mortalitySepsisSeptic shock

Identifiers

PMID42440543
PMCPMC13333373

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.