Evidence map›Paper›PMID 42440490›Full record

ArticleFrontiers in genetics2026

Epigenetic silencing of

Tianfu Guo, Yafei Li, Tiansheng He, Hui Luo, Yuwen Liu, Binhui Xie, Zhiping Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tianfu Guo *Key Laboratory of Innate Immunity and Chronic Inflammatory Diseases, Jiangxi Provincial Department of Education, Gannan Medical University, Ganzhou, China.
Yafei Li *School of Basic Medicine, Gannan Medical University, Ganzhou, China.
Tiansheng HeKey Laboratory of Innate Immunity and Chronic Inflammatory Diseases, Jiangxi Provincial Department of Education, Gannan Medical University, Ganzhou, China.
Hui LuoSchool of Basic Medicine, Gannan Medical University, Ganzhou, China.
Yuwen LiuThe First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Binhui XieThe First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Zhiping LiuKey Laboratory of Innate Immunity and Chronic Inflammatory Diseases, Jiangxi Provincial Department of Education, Gannan Medical University, Ganzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hepatocellular carcinoma (HCC) is characterized by extensive epigenetic alterations, particularly DNA methylation. Through integrated multi-omics analysis, we identified methylation-driven genes in HCC, including PHYHD1-a previously understudied candidate whose role in hepatocarcinogenesis remains unexplored. This study aimed to validate and functionally characterize PHYHD1 in HCC. Methods: Five pairs of HCC and adjacent non-tumor tissues were analyzed using whole-genome bisulfite sequencing (WGBS), RNA-seq, and TMT-based proteomics. We identified 97,523 differentially methylated regions (DMRs), 875 differentially expressed genes (DEGs), and 225 differentially expressed proteins (DEPs). Results: Integration of methylome, transcriptome, and proteome data revealed 19 consistently altered genes enriched in metabolic pathways. Discussion: Integrated multi-omics analysis identified

Indexed as

DNA methylationepigenetic silencinghepatocellular carcinomamulti-omicsPhyhd1

Identifiers

PMID42440490
PMCPMC13333458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.