SynthesisFrontiers in pharmacology2026
Meta-analysis of plant-derived exosome-like nanoparticles for the treatment of ulcerative colitis: efficacy and mechanisms insights.
Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Extracellular vesicle-based therapies in IBD: immunomodulation, regeneration, and translation.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Plant-Derived Exosome-Like nanoparticles (PELNs) are vital bioactive vesicles from medicinal plants, containing protective flavonoids, polyphenols, alkaloids, terpenoids, saponins, polysaccharides, and microRNAs. These compounds play crucial roles in PELNs' anti-inflammatory and other pharmacological effects. PELNs show promise as a treatment in animal experiments for ulcerative colitis (UC) due to their biocompatibility, low immunogenicity, and natural targeting abilities. This review examines their therapeutic effects on UC and the potential mechanisms behind their action. Methods: This study synthesises existing data through a meta-analysis, providing comprehensive preclinical evidence for the use of PELNs in ulcerative colitis. To identify studies examining the effects of PELNs on UC, the researchers conducted a comprehensive search of five databases. Results: This search identified a total of 25 eligible studies involving 304 animal subjects, with data up to 15 September 2025. According to the results of the meta-analysis, PELNs demonstrated significant effects in mitigating weight loss, increasing colon length, and reducing faecal consistency scores. Further mechanistic studies suggest that PELNs may exert their effects through multiple pathways. In addition to influencing inflammatory factors and the mucosal barrier, PELNs may also modulate the microbiota during the repair process of UC. PELNs intervention resulted in a statistically significant change in the Chao index ( Conclusion: This meta-analysis suggests that, in animal models of ulcerative colitis (UC), PELNs may be associated with antioxidant, anti-inflammatory, immunomodulatory and intestinal barrier-protective effects. This study only supports the correlational results derived from preclinical animal studies, and cannot confirm the definite action mechanisms nor clinical efficacy in humans. Further basic researches are still needed for in-depth exploration. Visit https://inplasy.com/inplasy-2025-11-0075/ to access the systematic review registration, labeled as INPLASY2025110075. Systematic Review Registration: Identifier INPLASY2025110075.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.