Evidence map›Paper›PMID 42440454›Full record

ArticleMolecular therapy. Oncology2026

Intraperitoneal delivery of the oncolytic virus CF17 improves tumor immunogenicity and survival in gastric cancer peritoneal metastasis.

Zhifang Zhang, Annie Yang, Anthony K Park, Shyambabu Chaurasiya, Sang-In Kim, Jianming Lu, Isabel Monroy, Hannah Valencia, Courtney Chen, Supriya Deshpande and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhifang ZhangDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Annie YangDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Anthony K ParkCancer Immunotherapeutics Program, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Shyambabu ChaurasiyaDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Sang-In KimDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Jianming LuDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Isabel MonroyCancer Immunotherapeutics Program, Beckman Research Institute, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Hannah ValenciaDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Courtney ChenDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Supriya DeshpandeDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Yuman FongDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.
Yanghee WooDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritoneal metastasis (PM) is the leading cause of treatment failure and death from gastric cancer (GC). We evaluated the antitumor and immunogenic effects of CF17, an oncolytic chimeric orthopoxvirus, in a novel syngeneic mouse model of GCPM. CF17 was tested in mouse GC cell lines (ACKPY3944 and ACKPY4113) for viral replication and cytotoxicity. A syngeneic mouse model of PM was established in C57BL/6 mice via intraperitoneal (IP) implantation of 1 × 10

Indexed as

gastric cancer peritoneal metastasesimmunotherapyintraperitoneal therapyoncolytic virotherapy

Identifiers

PMID42440454
PMCPMC13333358

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.