SynthesisFrontiers in nutrition2026
Vitamin D supplementation and mortality among critically ill adults: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Randomized controlled trials have failed to demonstrate the effects of vitamin D supplementation on reducing the mortality rate in critically ill adults. A Methods: The inclusion criteria for eligible studies were as follows: (1) randomized controlled trials; (2) critically ill adults; (3) the intervention group was given vitamin D or a vitamin D metabolite without any restrictions on type, dosage, duration, or route of administration; and (4). the outcome of mortality in critically ill adults. Results: Subgroup analysis revealed the following findings: (1) there was a trend toward reduced mortality in critically ill adults whose baseline 25-hydroxyvitamin D level was less than 20 ng/mL (RR = 0.87, Conclusion: This meta-analysis revealed that vitamin D supplementation significantly reduced mortality in critically ill adult patients, but not all patients benefited. The benefit was observed in three subgroups of patients as below: (1) critically ill adults with baseline 25-hydroxyvitamin D levels below 20 ng/mL; (2) critically ill adults receiving ≤300,000 IU of vitamin D supplementation; (3) critically ill adults receiving the supplement via intramuscular or intravenous injection. Systematic review registration: CRD420251152462.
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