ArticleEuropean journal of nuclear medicine and molecular imaging2026
Image quality and lesion detectability in simulated [
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCardiac sympathetic imaging with iodine-labeled metaiodobenzylguanidine (MIBG) is clinically relevant for assessing autonomic dysfunction and arrhythmic risk in heart failure. The development of positron-emitting
methodsAn anthropomorphic torso phantom with cardiac insert was prepared to simulate physiologic
resultsLAFOV PET/CT showed the best qualitative and quantitative performance overall. Lesion detectability was highest on LAFOV at all acquisition times, with digital SAFOV intermediate and analog SAFOV lowest. Image quality likewise favored LAFOV, especially at 5 and 10 min. In the pathological phantom, SNR increased from 25.9 to 75.1 on LAFOV, from 18.7 to 41.8 on digital SAFOV, and from 15.5 to 17.1 on analog SAFOV. At 10 min, exploratory uncorrected pairwise comparisons showed nominally higher SNR on LAFOV than on analog SAFOV PET/CT (75.1 vs 17.1, p = 0.028). For the transmural defect, CNR also increased most on LAFOV, with a nominally higher value versus analog SAFOV at 10 min (67.6 vs 14.5, p = 0.044). By contrast, for the low-contrast non-transmural defect, CNR was numerically higher on LAFOV at longer acquisition times, but the absolute inter-scanner differences were smaller and did not reach statistical significance.
conclusionLAFOV PET/CT provides superior image quality and lesion detectability for simulated cardiac
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