ArticleSurgery today2026
Fibroblast activation protein expression in fibrotic foci is a prognostic marker of fibrotic changes in lung tissue after surgical treatment for cancer.
Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated whether fibroblastic foci (FF) and fibroblast activation protein (FAP) expression in background fibrotic lung tissue are associated with the postoperative outcomes.
methodsBackground lung specimens with histologically confirmed fibrosis were obtained from 38 patients who underwent curative resection for primary lung cancer (2014 and 2018). The FF and FAP expressions were assessed using histology and immunohistochemistry. Overall survival (OS) was defined as the time from surgery to death from any cause and it was analyzed using Kaplan-Meier and Cox regression models. A Fine-Gray proportional subdistribution hazards model was used to evaluate the association between FAP expression in FF and respiratory events, treating lung cancer-related death as a competing risk.
resultsFifteen patients had a high FAP expression, while a low expression was observed in 23 patients. The baseline characteristics and pulmonary function were comparable between the groups. Multiple FF were more common in patients with a high FAP expression. A high FAP expression and honeycombing independently predicted a worse OS. A Fine-Gray analysis demonstrated that a high FAP expression in FF was significantly associated with an increased risk of respiratory events.
conclusionAn elevated FAP expression in FF is associated with a poorer respiratory-specific prognosis after lung cancer surgery in patients with coexisting pulmonary fibrosis, suggesting its potential utility for risk stratification and clinical management.
Indexed as
Identifiers
42439920What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.