ArticleAntimicrobial agents and chemotherapy2026
Primaquine-derived 5,6-orthoquinone concentrations in urine associated with CYP2D6 genotype-predicted phenotype and blood methemoglobin levels.
Mario Vernandes, Willy Agustine, Ihsan Fadilah, Michael Christian, Angela Rumaseb, Decy Subekti, Melva Louisa, Ric N Price, Kamala Thriemer, J Kevin Baird
Abstract read
In one paragraphArticle in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Mario VernandesFaculty of Medicine, Oxford University Clinical Research Unit Indonesia, Universitas Indonesia, Jakarta, Indonesia.ORCID 0009-0004-2268-536X Willy AgustineFaculty of Medicine, Oxford University Clinical Research Unit Indonesia, Universitas Indonesia, Jakarta, Indonesia.
Ihsan FadilahFaculty of Medicine, Oxford University Clinical Research Unit Indonesia, Universitas Indonesia, Jakarta, Indonesia.
Michael ChristianFaculty of Medicine, Oxford University Clinical Research Unit Indonesia, Universitas Indonesia, Jakarta, Indonesia.
Angela RumasebDivision of Global and Tropical Health, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
Decy SubektiFaculty of Medicine, Oxford University Clinical Research Unit Indonesia, Universitas Indonesia, Jakarta, Indonesia.
Melva LouisaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.ORCID 0000-0002-9451-0380 Ric N PriceCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Kamala ThriemerDivision of Global and Tropical Health, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
J Kevin BairdFaculty of Medicine, Oxford University Clinical Research Unit Indonesia, Universitas Indonesia, Jakarta, Indonesia.ORCID 0000-0002-2170-300X Funding
Wellcome TrustWellcome Trust B9R05430
6 · The paper itselfAbstract
Cytochrome P450 isotype 2D6 (CYP2D6) enzyme metabolizes the 8-aminoquinoline primaquine into its active form, 5-hydroxyprimaquine. Highly polymorphic CYP2D6 produces different enzyme activity levels among individuals. This diversity influences the therapeutic efficacy of primaquine in preventing
Indexed as
AntimalarialsCytochrome P-450 CYP2D6Malaria, VivaxMethemoglobinPrimaquineAdolescentAdultClinical Trials, Phase IV as TopicFemaleGenotypeHumansMaleMiddle AgedMulticenter Studies as TopicPhenotypePlasmodium vivaxAntimalarialsCytochrome P-450 CYP2D6MethemoglobinPrimaquine5,6-orthoquinone primaquineCYP2D6latencymalariaphenotypePlasmodium vivaxprimaquine
Identifiers
PMID42439801
PMCPMC13436372
What OpenQuestion holds
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LicenceCC BY
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