Evidence map›Paper›PMID 42439784›Full record

ArticleGenetics and molecular biology2026

Relationship between biomarkers and stroke risk in sickle cell disease odds in an Amazon folk.

Greice de L Cardoso-Costa, Fernando Mendes Paschoal Junior, Bruno Miranda, Alessandro Cardoso Rodrigues, Giovanna C Cavalcante, Caio S Silva, Saide Maria Sarmento Trindade, Sergio Antônio Batista Dos Santos, Milene Moraes Raiol, Cristina Maria Duarte Valente and 7 more

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Article in Genetics and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Greice de L Cardoso-CostaUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0000-0002-8916-0283
Fernando Mendes Paschoal JuniorInstituto AVC da Amazônia, Belém, PA, Brazil.
Bruno MirandaUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Alessandro Cardoso RodriguesUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Giovanna C CavalcanteUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Caio S SilvaUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Saide Maria Sarmento TrindadeFundação Centro de Hemoterapia e Hematologia do Pará (HEMOPA), Belém, PA, Brazil.
Sergio Antônio Batista Dos SantosFundação Centro de Hemoterapia e Hematologia do Pará (HEMOPA), Belém, PA, Brazil.
Milene Moraes RaiolUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Cristina Maria Duarte ValenteUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Leticia Dias MartinsUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Nelson Machado da Silva de LimaInstituto AVC da Amazônia, Belém, PA, Brazil.
Joelma Karin Sagica Fernandes PaschoalInstituto AVC da Amazônia, Belém, PA, Brazil.
Fernanda Andreza P L FigueiredoUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Sidney SantosUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Eric Homero Albuquerque PaschoalInstituto AVC da Amazônia, Belém, PA, Brazil.
Ândrea Ribeiro-Dos-SantosUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-7001-1483

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell disease (SCD) is defined by important heterogeneity between patients, but this clinical presentation mutability is not well understood. Therefore, this immense phenotypic variability calls for research into risk factors associated with greater chance of developing stroke in a specific population at Amazon forest. This study sought to explore the relationship between genetic markers of inflammatory process and the clinical risk of stroke in people with sickle cell anemia. The authors presented 70 patients (87.5%) were classified in group 1, without a stroke clinic, and 10 patients (12.5%) in group 2, with this clinic. These groups were subdivided in relation to the Doppler examination. Detailed analysis of genetic polymorphisms in specific subgroups revealed that variants in the CYP19A1 and MDM2 genes, in the group of patients without clinical stroke, showed statistical significance, indicating a possible protective effect against the stroke phenotype. Among patients who had a stroke, the variant in the CASP8 gene was statistically significant, suggesting that some genotypes may have a greater effect on the evolution of the stroke in patients with sickle cell anemia. Future studies should seek to include more patients with complete Doppler data and explore other variables that may affect stroke risk.

Identifiers

PMID42439784
PMCPMC13383251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.