Evidence map›Paper›PMID 42439684›Full record

ArticleCells2026

1,25-Dihydroxyvitamin D Induces a NURR1-Tyrosine Hydroxylase Transcriptional Axis Modulated by Rexinoid/RXR Signaling in Parkinson's Disease-Relevant Human Neural Cell Models.

Michael A Sausedo, Sanchita Mallick, Zhela L Sabir, Sarah Livingston, Quang T Nguyen, Mobin Emran Doost, Carl E Wagner, Pamela A Marshall, Carol A Haussler, Mark R Haussler and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael A SausedoSchool of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
Sanchita MallickSchool of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
Zhela L SabirSchool of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
Sarah LivingstonSchool of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
Quang T NguyenSchool of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
Mobin Emran DoostCollege of Medicine, University of Arizona, Phoenix, AZ 85004, USA.
Carl E WagnerSchool of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.
Pamela A MarshallSchool of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.ORCID 0000-0002-3530-4368
Carol A HausslerCollege of Medicine, University of Arizona, Phoenix, AZ 85004, USA.ORCID 0000-0001-8360-3066
Mark R HausslerCollege of Medicine, University of Arizona, Phoenix, AZ 85004, USA.ORCID 0000-0002-7097-1801
Peter W JurutkaSchool of Mathematical and Natural Sciences, Arizona State University, Glendale, AZ 85306, USA.ORCID 0000-0002-4950-9161

Funding

Assessing Novel Rexinoids Developed by Comparative Bioresponse Analysis in an Innovative Mouse Model of Cutaneous T Cell LymphomaR15CA249617 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI JURUTKA, PETER W, WAGNER, CARL EDWARD · 2020 to 2020
$484k
NCI NIH HHS R15 CA249617NIH HHS 1R15CA249617-03
6 · The paper itself

Abstract

The hormonal vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25D), produced primarily in the kidney, acts in numerous end-organs via the nuclear vitamin D receptor (VDR) to trigger molecular events that orchestrate bone mineral homeostasis, immune responsiveness, and aspects of behavior. Tyrosine hydroxylase (TH) encodes a neuronally expressed enzyme that catalyzes the initial, rate-limiting step in the production of several catecholamine neurotransmitters and hormones, including dopamine, norepinephrine, and epinephrine. Herein we report that

Indexed as

NeuronsNuclear Receptor Subfamily 4, Group A, Member 2Parkinson DiseaseRetinoid X ReceptorsSignal TransductionTranscription, GeneticTyrosine 3-MonooxygenaseVitamin DAnimalsCell Line, TumorHumansMicePromoter Regions, GeneticReceptors, CalcitriolRNA, Messenger1,25-dihydroxyvitamin DNR4A2 protein, humanNuclear Receptor Subfamily 4, Group A, Member 2Receptors, CalcitriolRetinoid X ReceptorsRNA, MessengerTyrosine 3-MonooxygenaseVitamin Ddopaminergic neuronsgene expressionNURR1Parkinson’s diseaserexinoidsRXR/VDRtyrosine hydroxylasevitamin D

Identifiers

PMID42439684
PMCPMC13359966

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.