ArticleThe Laryngoscope2026
Vocal Outcomes After Cell-Based Outer Vocal Fold Implant in Porcine Bilateral Vocal Fold Resection.
Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Vocal Outcomes After Cell-Based Outer Vocal Fold Implant in Porcine Bilateral Vocal Fold Resection.The Laryngoscope · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveCell-based outer vocal fold replacement (COVR) consists of human adipose-derived stem cells and is a potential treatment for severe vocal fold injury. Prior rabbit studies demonstrated enhanced wound healing and COVR's safety in pigs. Building on prior work defining pig-specific acoustic parameters, this study evaluates phonatory recovery and establishes quantitative voice assessment frameworks following bilateral cordectomy and COVR implantation in a large animal model.
methodsCOVR implantation was performed in eight Yucatan mini-pigs after bilateral vocal fold resection. Functional voice recovery was tracked, with spontaneous vocalizations recorded pre- and post-surgery for up to 6 months. Pig squeals were extracted using Python, manually verified, and nonrepresentative sounds excluded. Acoustic features including Q50 (median frequency of spectral energy), flux (rate of spectral energy change), F0 (fundamental frequency), jitter (period perturbation), and shimmer (amplitude perturbation) were analyzed using linear mixed-effect models and Wilcoxon rank sum test with Benjamini-Yekutieli correction. After 6 months, larynges were harvested and human cells were sought via fluorescent in situ hybridization.
resultsQ50 significantly decreased immediately postoperatively (p < 0.001) and returned to preoperative range by 6 months, while F0 and flux changed modestly over time. Human cells persisted in 7 of the 8 subjects.
conclusionsCOVR implantation improved key nonperiodic acoustic parameters 6 months after extensive laryngeal injury in pigs. Implanted cells were detected after 6 months. Future work includes one-year monitoring to assess long-term voice recovery and extracellular matrix remodeling, artificial intelligence integration for expanded acoustic analysis, and a unilateral injury model comparing control cordectomy alone versus COVR reconstruction. LEVEL OF EVIDENCE: N/A.
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