ArticlemBio2026
Concentration-dependent dual activity of a phage-encoded lysin modulates infection dynamics in mycobacteriophage D29.
Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lytic enzymes encoded by bacteriophages are conventionally understood to serve a single function in the phage life cycle: to enable progeny release through host cell lysis. Here, we identify an unexpected dual functionality in LysB, a lytic cassette protein of mycobacteriophage D29, which exerts opposing effects on phage propagation depending on the stage of infection. In our model, during the early phase of phage expansion, LysB's activity is limited to infected cells, hydrolyzing their outer membrane to facilitate efficient virion release. However, as the infection progresses, LysB accumulates in the extracellular environment, eventually reaching levels sufficient to act on uninfected bystander cells, rendering them resistant to infection. Consistent with this model, deletion of
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