Evidence map›Paper›PMID 42439363›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Risk of Inflammatory Bowel Disease Following Hospital-Treated Infections and Modulatory Role of Host Genetics to Support a Multi-Hit Pathogenesis Model.

Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F Ludvigsson, Tian Fu, Candida Abreu and 7 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Haiming ZhuangDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Lintao DanDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.ORCID https://orcid.org/0000-0001-5963-2772
Xin XiangDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.
Xixian RuanDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.ORCID https://orcid.org/0000-0002-4937-9168
Shuai YuanDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jialu YaoDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jiawei GengDepartment of Big Data in Health Science School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China.ORCID https://orcid.org/0000-0002-7622-2692
Jonas F LudvigssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Tian FuDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.
Candida AbreuDepartment of Infectious Diseases, Faculty of Medicine, Centro Hospitalar S. João, Nephrology Research and Development Unit, University of Porto, Porto, Portugal.
Laurent Peyrin-BirouletDepartment of Gastroenterology, Université De Lorraine, CHRU Nancy, France.
Xue LiDepartment of Big Data in Health Science School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Yi XiaoDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.ORCID https://orcid.org/0000-0002-5124-8378
Fernando MagroCINTESIS@RISE Department, Faculdade De Medicina da Universidade do Porto, Porto, Portugal.
Xiaoyan WangDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.
Jing SunDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.ORCID https://orcid.org/0000-0003-0310-975X
Jie ChenDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, P. R. China.ORCID https://orcid.org/0000-0002-4029-4192

Funding

Central South University Clinical Research Zhang Xiao-qian Program ZXQ2026A06China Postdoctoral Science Foundation 2025M782332China Postdoctoral Science Foundation GZC20251322National Natural Science Foundation of China 82170553National Natural Science Foundation of China 82204019National Natural Science Foundation of China 82270575National Natural Science Foundation of China 82470543National Natural Science Foundation of China 82500637National Natural Science Foundation of China U23A20492Natural Science Foundation of Changsha kq2502174Natural Science Fund for Distinguished Young Scholars of Zhejiang Province LRG26H260001Natural Science Fund for Excellent Young Scholars of Hunan Province 2025JJ40083Qingfeng Scientific Research Fund of the China Crohn's & Colitis Foundation CCCF-QF-2023Z02-02Science Fund for Creative Research Groups of the Natural Science Foundation of Hunan Province 2024JJ1014Scientific Research Program of FuRong Laboratory 2023SK2085-3
6 · The paper itself

Abstract

Infectious diseases can cause lasting immune disturbances, but whether they contribute to later inflammatory bowel disease (IBD) is unclear. Hospital-treated infections may be especially informative because they reflect substantial immune challenge, yet their relation to IBD risk and the role of host genetics remain poorly defined. It examines hospital-treated infections and incident IBD in a prospective cohort and integrates gene-environment interaction analyses to identify susceptibility pathways and develop a post-infection risk score. Hospital-treated infections of multiple pathogen types and sites were associated with higher subsequent IBD risk. This association is stronger in carriers of immune-related risk variants, with Crohn's disease linked mainly to innate immune and autophagy pathways and ulcerative colitis to JAK-STAT, T-cell differentiation, and chemokine signaling. An Infection IBD Score based on 44 immune-related genes stratified post-infection risk. These findings support infections as triggers of IBD in genetically susceptible individuals and highlight a potential tool for risk stratification.

Indexed as

genetic susceptibilityinfectioninflammatory bowel disease

Identifiers

PMID42439363
PMCPMC13359404

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.