SynthesisColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2026
Salvage abdominoperineal resection for anal squamous cell carcinoma: A systematic review and meta-analysis of proportions.
Synthesis in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
aimSalvage abdominoperineal resection (APR) remains the standard treatment for patients with persistent or recurrent anal squamous cell carcinoma after chemoradiotherapy (CRT). This study aimed to evaluate the perioperative and oncological outcomes of salvage abdominoperineal resection.
methodsA systematic review of observational studies including adult patients with persistent or recurrent anal squamous cell carcinoma undergoing salvage APR after failure of CRT was conducted using PubMed, Scopus and Cochrane through March 2026. Binary outcomes were pooled as proportions on the logit scale under random-effects models; a generalized linear mixed model was applied when zero-event studies were present. Continuous outcomes as means with 95% confidence intervals (CIs). Heterogeneity was assessed using the I
resultsEighteen observational studies comprising 1,013 patients were included. The pooled 2-year and 5-year overall survival (OS) rates were 68.34% (95% CI: 60.42-75.33; I
conclusionSalvage APR for anal squamous cell carcinoma demonstrated moderate long-term survival, acceptable R0 resection rates and substantial postoperative morbidity. However, the available evidence remains limited by high heterogeneity, non-standardized outcome definitions and the absence of comparative data.
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