Evidence map›Paper›PMID 42439163›Full record

ArticleJournal of the American Chemical Society2026

Nature Counts to Three: Universal Mg-Pinch Motif Polarizes the Cleaved Bond in NTP-Processing Enzymes.

Balint Dudas, Dénes Berta, Pablo Jambrina, Pedro J Buigues, Reynier Suardiaz, Silvia Gómez-Coca, Wenhao Deng, Bernard R Brooks, Beáta G Vértessy, Edina Rosta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. MgJournal of the American Chemical Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Balint DudasDepartment of Physics and Astronomy, University College London, London WC1E 6BT, U.K.ORCID 0000-0001-6938-5816
Dénes BertaDepartment of Physics and Astronomy, University College London, London WC1E 6BT, U.K.
Pablo JambrinaDepartment of Physical Chemistry, University of Salamanca, 37008 Salamanca, Spain.ORCID 0000-0001-8846-3998
Pedro J BuiguesItalian Institute of Technology, 16163 Genova, Italy.
Reynier SuardiazDepartment of Physical Chemistry, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-1035-9020
Silvia Gómez-CocaDepartment of Inorganic and Organic Chemistry and Institute of Theoretical and Computational Chemistry,University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-2299-4697
Wenhao DengDepartment of Physics and Astronomy, University College London, London WC1E 6BT, U.K.
Bernard R BrooksLaboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-3586-2730
Beáta G VértessyDepartment of Applied Biotechnology and Food Science, Budapest University of Technology and Economics, 1111 Budapest, Hungary.
Edina RostaDepartment of Physics and Astronomy, University College London, London WC1E 6BT, U.K.ORCID 0000-0002-9823-4766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphates are essential for life in all organisms, playing key roles in nucleic acids, signaling, energy transfer, and biosynthesis. We conducted a quantitative analysis of nucleoside triphosphate (NTP) processing enzymes across all enzymatic reactions, revealing their dominance in phosphate reactivity with ATP as the most prevalent substrate. Two main reaction types occur predominantly: cleavage resulting in pyrophosphate release or phosphate release/transfer. The large majority of NTP processing enzymes require divalent Mg

Indexed as

MagnesiumNucleotidesCatalytic DomainDensity Functional TheoryModels, MolecularMagnesiumNucleotides

Identifiers

PMID42439163
PMCPMC13397572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.