ArticleAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica2026
No Sex Differences in the Amount of Type IV Collagen in Wistar Rats Regardless of Sampling Strategy.
Article in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Serum collagen IV (Col IV) is an important marker for staging liver fibrosis, but histological baselines in healthy tissue are often lacking or biased. This study applied unbiased stereological sampling to quantify liver Col IV in healthy adult Wistar rats and assess sex differences. No significant differences were observed between sampling strategies (simple, systematic, or stratified random) or between males (4.26% ± 0.93%) and females (3.71% ± 1.27%), yielding a pooled mean of 3.96% ± 1.11%. The Col IV-positive area (3.62% ± 1.29%) did not differ significantly from the total collagen area measured by Sirius red (3.06% ± 1.72%), although a statistical trend was noted (R
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