Evidence map›Paper›PMID 42438994›Full record

ArticleMacromolecular bioscience2026

Dual-Functional Antibiotic Adjuvants Based on Antibacterial Polyesters With Guanidinium and Boronic Acid Motifs.

Yi-Lin Qian, Wei Li, Yang Cheng, Qing Liu, Xiao-Tuan Zhang, Fu-Sheng Du, Zi-Chen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi-Lin QianBeijing National Laboratory for Molecular Sciences, Center For Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry & Molecular Engineering, Peking University, Beijing, China.
Wei LiDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.ORCID https://orcid.org/0000-0002-6557-3948
Yang ChengDepartment of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.
Qing LiuSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi Province, China.
Xiao-Tuan ZhangDepartment of Clinical Laboratory, The Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China.
Fu-Sheng DuBeijing National Laboratory for Molecular Sciences, Center For Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry & Molecular Engineering, Peking University, Beijing, China.
Zi-Chen LiBeijing National Laboratory for Molecular Sciences, Center For Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry & Molecular Engineering, Peking University, Beijing, China.ORCID https://orcid.org/0000-0002-0746-9050

Funding

Hunan Provincial Key Laboratory of Basic and Clinical Pharmacological Research on Gastrointestinal Tumors 2023TP1014National Key R&D Program of China 2021YFA1201200Natural Science Foundations of Hunan Province 2025JJ60589Natural Science Foundations of Hunan Province 2025JJ90134
6 · The paper itself

Abstract

This study addresses the challenge of antimicrobial resistance in Gram-negative bacteria by developing a novel class of biodegradable polymeric antibiotic adjuvants. We have engineered cationic polyesters functionalized with guanidinium and phenylboronic acid (PBA) groups through the one-pot thiol-Michael addition post-modification to create a dual-targeting mechanism against the bacterial outer membrane (OM). This design combines the membrane-disruptive action of guanidinium with the specific binding capability of PBA to lipopolysaccharides. The relationships between structure of the polymers and their antibacterial ability or cytocompatibility were explored. The optimized polymer, G95-BA5, exhibited potent intrinsic bactericidal activity and good biocompatibility. It also demonstrated remarkable in vitro synergy with rifampicin against multidrug-resistant pathogens, achieving fractional inhibitory concentration indices as low as 0.06 by significantly enhancing the outer membrane permeability. In a lethal murine peritonitis model, the combination of G95-BA5 and rifampicin provided 100% survival, drastically reduced bacterial burden in vital organs, and controlled systemic inflammation. This work establishes an effective polymer platform for overcoming the OM permeability-based resistance and revitalizing existing antibiotics.

Indexed as

Anti-Bacterial AgentsBoronic AcidsGuanidinePeritonitisPolyestersAnimalsMiceMicrobial Sensitivity TestsRifampinAnti-Bacterial Agentsbenzeneboronic acidBoronic AcidsGuanidinePolyestersRifampinantibacterial polymerantibiotic adjuvantguanidinium‐functionalized polyesterphenylboronic acidsynergistic effect

Identifiers

PMID42438994
PMCPMC13358685

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.