Evidence map›Paper›PMID 42438972›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Asymmetric Total Synthesis of (+)-Ineleganolide.

Changhong Han, Yichi Zhang, Yuxin Tian, Ziang Ding, Zhou Pan, Junhong Li, Weiwu Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Changhong HanMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Yichi ZhangMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Yuxin TianMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Ziang DingMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Zhou PanMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Junhong LiMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Weiwu RenMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.ORCID 0000-0002-9485-1679

Funding

National Natural Science Foundation of China 22171251Natural Science Foundation of Shandong Province ZR2024MB122
6 · The paper itself

Abstract

Polycyclic cembrane diterpenoids and norditerpenoids have garnered sustained interest from the synthetic community due to their unique polycyclic frameworks and promising biological activities. Herein, we report a 13-step total synthesis of (+)-ineleganolide, a highly oxidized cembrane norditerpenoid possessing a synthetically challenging [6,7,5,5,5] cage-type pentacyclic scaffold. This synthesis is highlighted by a novel strategy relying on an intramolecular Diels-Alder reaction that stereoselectively constructs the pivotal [6,6,5,5,5] pentacyclic framework as a single diastereoisomer, addressing stereochemical control challenges. In the late-stage elaboration, a tandem epoxidation/Meinwald rearrangement efficiently forges the sterically congested central seven-membered ring. This synthetic strategy provides a new blueprint for accessing other members of the cembrane norditerpenoid family.

Indexed as

DiterpenesCycloaddition ReactionMolecular StructureStereoisomerismDiterpenesineleganolidecembrane norditerpenoidsDiels‐Alder reaction(+)‐ineleganolideMeinwald rearrangementtotal synthesis

Identifiers

PMID42438972
PMCPMC13528549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.