ArticlePediatrics international : official journal of the Japan Pediatric Society
Mortality Stratification With Pediatric SOFA and Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Article in Pediatrics international : official journal of the Japan Pediatric Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the previous study, persistent inflammation, immunosuppression, and catabolism syndrome in pediatrics (PIICS-p) criteria identified a subgroup with poor long-term prognosis. Pediatric sequential organ failure assessment (pSOFA) score is a well-known predictor of short-term mortality. We hypothesized that combining the pSOFA score and PIICS-p criteria could provide more comprehensive risk stratification.
methodsWe conducted a retrospective cohort study in a PICU. Included were 285 eligible patients aged zero to 19 years with 15 days or longer of PICU stay between January 2019 and December 2023. The primary outcomes were death during the observation period and time from PICU day 14 to death. Patients were classified on PICU day 14: high pSOFA (> 8) or low, subsequently stratified by PIICS-p or not.
resultsThe overall mortality rate was 47% (35/75) in high pSOFA, 32% (8/25) in low pSOFA/PIICS-p, and 10% (18/185) in low pSOFA/non-PIICS-p group (p < 0.001). In a multivariable Cox proportional hazards model, high pSOFA (HR 6.33, 95% CI 3.43-11.7, p < 0.001) and low pSOFA/PIICS-p (HR 3.14, 95% CI 1.28-7.69, p = 0.012) were identified as significant risk factors for mortality. The Kaplan-Meier curves showed significant differences among the three groups (p < 0.001). The high pSOFA group showed an early decline in survival. Survival in the low pSOFA/PIICS-p group was lower than that in the low pSOFA/non-PIICS-p group, and the difference widened over time.
conclusionIntegration of pSOFA and PIICS-p enables three-group mortality stratification in critically ill children and early recognition of late-mortality risk among those who appear low risk acutely.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.