ArticlePhysical activity and nutrition2026
Effects of high-intensity aerobic exercise during multiple cycles of doxorubicin treatment on cardiac catabolism.
Article in Physical activity and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeDoxorubicin causes dose-dependent cardiotoxicity characterized by cardiac atrophy. Although moderate-intensity aerobic exercise may mitigate doxorubicin cardiotoxicity, the effects of high-intensity aerobic exercise during doxorubicin treatment on cardiac homeostasis remain unclear. Therefore, this study investigated the impact of high-intensity aerobic exercise (EXE) during doxorubicin (DOX) chemotherapy on cardiac autophagy, protein catabolism, and lipolysis.
methodsMale C57BL/6J mice were randomized into sedentary-saline, exercise-saline, sedentary-doxorubicin, and exercise-doxorubicin groups. Doxorubicin was administered intraperitoneally (5 mg/kg, 5 times at 2-week intervals, totaling 25 mg/kg). The exercise groups performed high-intensity treadmill running (12-15 m/min, 60 min/day, for 7 weeks) during doxorubicin treatment. Body and heart weights were measured, and cardiac tissues were analyzed via Western blotting.
resultsDoxorubicin reduced the body and heart weights, and the combination of exercise and doxorubicin further exacerbated these effects. While exercise administered during doxorubicin treatment improved autophagic flux and enhanced lipolysis, it significantly exacerbated cardiac protein catabolism, as evidenced by decreased structural proteins (β-actin, Talin), upregulated ubiquitin-proteasome system components, and increased proteolytic cleavage in the exercise-doxorubicin group compared to the sedentary-doxorubicin group. These findings demonstrate a complex interaction between exercise during doxorubicin treatment, while simultaneously promoting the clearance of damaged components through enhanced lipid utilization and amplifying the degradation of essential cardiac structural proteins.
conclusionThese results suggest that concurrent high-intensity aerobic exercise during cardiotoxic chemotherapy regimens may compromise myocardial integrity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.