Evidence map›Paper›PMID 42438834›Full record

ArticleMolecular therapy. Nucleic acids2026

Prime editing enables isogenic modeling of PNPLA3-I148M-associated lipotoxicity in hepatocytes.

Haruna Noguchi, Takuro Uchida, Naoki Wakita, Mitsumasa Takenaga, Tetsushi Sakuma, Serami Murakami, Mitsuki Inomata, Atsushi Ono, Hiroko Hagiwara, Yuka Hirashita and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Haruna NoguchiDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Takuro UchidaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Naoki WakitaGraduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Mitsumasa TakenagaGraduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima 739-8551, Japan.
Tetsushi SakumaGraduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Serami MurakamiDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Mitsuki InomataDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Atsushi OnoDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Hiroko HagiwaraCell Innovator Inc., Fukuoka 821-8582, Japan.
Yuka HirashitaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Sotaro OzakaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Kei MoriDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Tomoko TokumaruDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Tomoko SaitoDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Masao IwaoDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Mie ArakawaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Mizuki EndoDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Masaaki KodamaDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Kazuhiro MizukamiDepartment of Gastroenterology, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The PNPLA3-I148M (rs738409 C>G) variant is a well-established genetic determinant of hepatic steatosis, fibrosis, and hepatocellular carcinoma. However, its precise functional impact on hepatocyte physiology remains incompletely understood. Here, we employed a GFP-linked all-in-one prime editing system to generate isogenic HepG2 clones representing all

Indexed as

isogenic hepatocyte modellipid droplet accumulationlipotoxic stressMASLDMT: Clinical Applicationspalmitic acidPNPLA3-I148Mprime editingtranscriptomic profiling

Identifiers

PMID42438834
PMCPMC13356686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.