Evidence map›Paper›PMID 42438824›Full record

ArticleiScience2026

Adenylyl cyclase 9: Fundamental change of regulation in vertebrates and gene sub-functionalization after teleost-specific whole-genome duplication.

Ferenc A Antoni, Julie Mazzolini, Heather McClafferty, Zhiaho Chen, Laura Szalai, Cristina Xia, Sahad Iqbal, Martin Denvir, András Balla, Dirk Sieger and 2 more

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ferenc A AntoniCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.
Julie MazzoliniCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.
Heather McClaffertyCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.
Zhiaho ChenCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.
Laura SzalaiDepartment of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Cristina XiaCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.
Sahad IqbalCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.
Martin DenvirCardiovascular Research Centre, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK.
András BallaDepartment of Physiology, Semmelweis University, 1094 Budapest, Hungary.
Dirk SiegerCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.
Michael J ShipstonCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.
Paul SkehelCentre for Discovery Brain Sciences, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH9 9XD, Scotland, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In mammals, transmembrane adenylyl cyclase 9 (AC9) is resistant to regulation by cell surface receptors coupled to heterotrimeric G proteins. A major facet of this resistance is auto-inhibition-in the presence of activated Gsa, AC9 is inhibited by its C-terminal domain. Here, we examined the evolution of this seemingly paradoxical control mechanism. The hallmarks of auto-inhibition are apparent in all vertebrates; none are found in invertebrates. Teleost-specific whole genome duplication (TGD) resulted in

Indexed as

adenylyl cyclaseauto-inhibitionG protein coupled receptorsmedakawhole genome duplicationzebrafish

Identifiers

PMID42438824
PMCPMC13356687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.