Synthesis and systematic evaluation of four stereoisomers of BMS compound A enabled by a diastereoselective cyclopropanation on a chiral ketal intermediate.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Feijun WangChemical Biology and Medicinal Chemistry Division, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA kevinf@unc.edu.
John N HansonMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda Maryland USA sibleyd@ninds.nih.gov.
Snezana T DimovaMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda Maryland USA sibleyd@ninds.nih.gov.ORCID https://orcid.org/0009-0004-1665-6212
Jayachandra RayadurgamChemical Biology and Medicinal Chemistry Division, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA kevinf@unc.edu.
Camryn J FultonDepartment of Pharmacology, UNC School of Medicine, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.ORCID https://orcid.org/0009-0006-3903-2132
Amy E MoritzMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda Maryland USA sibleyd@ninds.nih.gov.
Ashley N NilsonMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda Maryland USA sibleyd@ninds.nih.gov.
William A HearneDepartment of Chemistry X-ray Crystallography Core, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Chun-Hsing ChenDepartment of Chemistry X-ray Crystallography Core, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.ORCID https://orcid.org/0000-0003-0150-9557
Ryan H GumpperChemical Biology and Medicinal Chemistry Division, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA kevinf@unc.edu.
David R SibleyMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda Maryland USA sibleyd@ninds.nih.gov.ORCID https://orcid.org/0000-0002-0624-962X
Kevin J FrankowskiChemical Biology and Medicinal Chemistry Division, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA kevinf@unc.edu.ORCID https://orcid.org/0000-0002-7173-6352
Funding
Molecular And Pharmacological Studies Of Dopamine ReceptorsZIANS002263 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SIBLEY, DAVID · 2009 to 2025
$37.4M
Request for a 500 MHz NMR console and nitrogen-cooled cryoprobeS10OD032476 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, ANDREW L · 2022 to 2022
$599k
D1 dopamine receptor positive allosteric modulators as a practical treatment for cognitive declineR21AG068833 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANKOWSKI, KEVIN J. · 2021 to 2022
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Synthesis and systematic evaluation of four stereoisomers of BMS compound A enabled by a diastereoselective cyclopropanation on a chiral ketal intermediate. · full record | OpenQuestion