ArticleGenetics in medicine open2026
The distinct molecular profile of metastatic prostate cancer in the mixed Brazilian population.
Article in Genetics in medicine open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The carcinogenesis of metastatic prostate cancer results from complex interactions between genetic and environmental factors. The genomic profiles of admixed populations, such as Brazilians, are still poorly explored, offering an opportunity to better understand the contribution of germline and somatic variants in these patients. Methods: In this multicenter study, 193 men with metastatic prostate cancer, who underwent matched tumor-normal exome sequencing, were enrolled from all five Brazilian macro-regions. Results: Pathogenic and likely pathogenic germline variants in well-known prostate cancer genes were identified in only 5.7% of the patients, with one case (0.5%) harboring the Conclusion: Even with the low success rate of tumor samples, our data demonstrated that most loss-of-function variants in homologous recombination pathway genes occur as somatic events. Our findings also highlight the distinct germline genomic profile of the Brazilian population and underscore the challenges associated with performing comprehensive analyses on formalin-fixed paraffin-embedded samples.
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