ReviewToxicology reports2026
Multi-omics integration deciphers arsenic-induced multi-organ toxicity and the novel ferroptosis axis.
Review in Toxicology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Chronic arsenic exposure threatens over 200 million people worldwide and induces multi-organ injury, yet the panoramic molecular reprogramming across organs remains incompletely understood, and traditional single-omics approaches fail to capture cross-level and cross-organ regulatory associations. This review systematically integrates evidence from global epidemiology to single-cell spatial omics, tracing the evolution of multi-omics technologies-from single-platform profiling to data fusion strategies such as coupled matrix factorization (CMF) and the DIABLO framework, two complementary multi-omics integration approaches-and to cutting-edge spatial transcriptomics. We highlight ferroptosis as a common mechanism in arsenic-induced multi-organ injury. At the molecular level, we propose a mechanistic model wherein arsenic (AsIII) disrupts selenium metabolism by inhibiting Sec-tRNA
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